GABA thiab Ketogenic Diets
Kwv yees li ntawm lub sijhawm nyeem ntawv: 5 feeb
Peb yuav tsum tau tham txog lub luag haujlwm ntawm GABA hauv kev puas siab puas ntsws thiab mob hlwb. Thiab tom qab ntawd, kuv yuav piav qhia rau koj vim li cas ketones tuaj yeem pab tswj cov kab mob neurotransmitter no.
GABA yog dab tsi?
GABA (gamma-aminobutyric acid) yog lub ntsiab inhibitory neurotransmitter nyob rau hauv lub hlwb, thiab nws plays lub luag hauj lwm tseem ceeb nyob rau hauv regulating neuronal excitability thiab tswj qhov sib npaug ntawm neuronal excitation thiab inhibition.
GABAergic dysfunction tau cuam tshuam rau ntau yam kev puas siab puas ntsws thiab paj hlwb, nrog rau kev ntxhov siab, kev nyuaj siab, qaug dab peg, schizophrenia, thiab autism spectrum disorders.
Kev hloov pauv hauv GABA signaling tuaj yeem hloov pauv qhov sib npaug ntawm excitatory thiab inhibitory neurotransmission hauv lub hlwb, ua rau muaj ntau yam tsos mob nyob ntawm thaj tsam ntawm lub hlwb thiab circuits.
Kev kuaj mob dab tsi pom muaj teeb meem nrog GABA?
Ntau ntau.
Kev ntxhov siab thiab kev nyuaj siab feem ntau tshwm sim los ntawm qhov tsis sib xws ntawm excitatory thiab inhibitory neurotransmission hauv lub hlwb xws li amygdala thiab prefrontal cortex. Txo GABA signaling nyob rau hauv cov cheeb tsam no tuaj yeem ua rau muaj zog neuronal excitability thiab hyperarousal, uas yuav ua rau muaj kev ntxhov siab thiab kev xav tsis zoo.
Kev qaug dab peg yog ib qho kev puas siab puas ntsws uas tshwm sim los ntawm kev qaug dab peg, thiab nws feem ntau cuam tshuam nrog kev cuam tshuam hauv GABA signaling. Txo GABA signaling tuaj yeem ua rau hyperexcitability thiab qaug dab peg, thaum nce GABA signaling tuaj yeem ua rau sedation thiab anticonvulsant teebmeem.
Schizophrenia yog ib qho kev puas siab puas ntsws uas cuam tshuam nrog kev txawv txav hauv ntau lub tshuab neurotransmitter, suav nrog GABA. Txo GABA signaling nyob rau hauv lub prefrontal cortex thiab lwm cheeb tsam ntawm lub paj hlwb tau cuam tshuam rau cov kev txawj ntse tsis txaus thiab cov tsos mob zoo (xws li hallucinations thiab delusions) ntawm schizophrenia.
Autism spectrum disorders yog neurodevelopmental disorders uas yog tus cwj pwm los ntawm kev sib txuas lus tsis zoo thiab kev coj cwj pwm rov ua dua. GABAergic dysfunction tau cuam tshuam rau hauv pathophysiology ntawm autism, thiab kev hloov pauv hauv GABA signaling tau pom nyob rau hauv ntau lub hlwb hauv cov neeg uas muaj autism.
Ketones thiab GABA
Yuav ua li cas yog tag nrho cov no ua rau kev noj haus ketogenic? Kuv yuav hais rau nej. Vim kuv xav kom koj nkag siab txhua txoj hauv kev uas koj tuaj yeem hnov zoo dua. ⬇️ ib
D-β-hydroxybutyrate (BHB; lub cev ketone) tau pom los txhim kho GABA signaling nyob rau hauv lub hlwb, uas tej zaum yuav muaj txiaj ntsig zoo rau kev paub txog kev ua haujlwm thiab kev puas hlwb.
Acetoacetate (lwm lub cev ketone) kuj tau pom los hloov GABA signaling hauv lub hlwb. Peb tseem tab tom nrhiav seb yuav ua li cas, tab sis cov nyhuv yog kiag li muaj.
Ib txoj kev npaj rau acetoacetate cov nyhuv ntawm GABA signaling yog tias nws yuav ua rau kom muaj GABA los ntawm kev txhim kho cov haujlwm ntawm GABA-synthesizing enzyme glutamic acid decarboxylase (GAD).
GAD (enzyme) xav tau cov cofactor pyridoxal 5′-phosphate (PLP) rau nws cov dej num, thiab acetoacetate (lub cev ketone) tau pom tias yuav ua rau kom muaj PLP hauv lub hlwb. Qhov no tuaj yeem ua rau nce GABA synthesis thiab tso tawm, ua rau txhim kho GABA signaling. Rau cov uas tsis paub, PLP yog daim ntawv nquag ntawm B6. Vitamin B6 koom nrog hauv cov metabolism ntawm cov amino acids, cov synthesis ntawm neurotransmitters xws li serotonin thiab dopamine, thiab kev tswj ntawm cov noob qhia.
Nco tseg: Qhov no yog vim li cas kuv thiaj li nyiam ua ke cov zaub mov ketogenic nrog kev noj zaub mov ntau ntxiv thaum kho. Muaj kev sib koom ua ke!
Lwm qhov kev xav tau yog tias acetoacetate tuaj yeem hloov kho GABA receptors, uas yog cov proteins uas kho cov teebmeem ntawm GABA ntawm neuronal excitability.
Acetoacetate tau pom tias txhim khu kev ua haujlwm ntawm GABA-A receptors hauv lub hlwb. GABA yog ib qho neurotransmitter hauv lub hlwb uas pab tswj lub hlwb ua haujlwm. Muaj ob hom receptors uas GABA tuaj yeem khi rau, hu ua GABA-A thiab GABA-B receptors. GABA-A receptors ua sai sai los nres cov neurons los ntawm kev tua, thaum GABA-B receptors ua haujlwm qeeb dua los txo kev ua haujlwm hauv lub hlwb. Ob hom receptors yog qhov tseem ceeb rau kev tswj hwm qhov sib npaug ntawm lub hlwb ua haujlwm thiab so.
xaus
Yog li ntawd koj muaj nws. Tam sim no koj nkag siab ntau ntxiv txog yuav ua li cas kev noj zaub mov ketogenic pab sib npaug ntawm cov neurotransmitter GABA thiab qhov cuam tshuam qhov no muaj rau kev kho mob ntawm ntau yam kab mob neurological thiab mob hlwb.
Tawm mus thiab ua qhov kev txiav txim siab paub zoo dua hauv koj txoj kev rov qab los ntawm kev puas siab puas ntsws thiab mob hlwb!
Yog tias koj tshawb nrhiav hauv qhov blog no (hauv qab nplooj ntawv) ntawm koj qhov kev kuaj mob, koj yuav pom ib tsab xov xwm hais txog kev cuam tshuam GABA raws li nws siv rau koj qhov kev kuaj mob tshwj xeeb. Nov yog qee qhov ntawm cov uas koj yuav xav tau!
Thiab yog tias koj xav tau kev pab kawm yuav ua li cas siv cov khoom noj ketogenic thiab ua rau koj tus kheej ntxiv thiab kev ua neej hloov pauv mus rau lub hlwb zoo dua, koj zoo siab tos txais mus saib kuv Qhov Kev Pabcuam Mob Hlwb Fog Recovery.
References
Brownlow, ML, Benner, B., D'Agostino, D., Gordon, MN, & Morgan, D. (2020). Kev noj haus Ketogenic txhim kho kev nco tsis zoo tshwm sim los ntawm kev cuam tshuam rau hypobaric hypoxia hauv txiv neej Sprague-Dawley nas. PloS ib, 15(2), e0228763. DOI: 10.1371/journal.pone.0228763 ib
Cahill, GF (2006). Roj metabolism hauv kev tshaib plab. Kev tshuaj xyuas txhua xyoo ntawm kev noj haus, 26, 1-22. DOI: 10.1146/annurev.nutr.26.061505.111258
D'Andrea Meira, I., Romão, TT, Pires, DO, da Silva-Maia, JK, & de Oliveira, GP (2021). Ketogenic noj thiab qaug dab peg: dab tsi peb paub txog tam sim no. Frontiers in neuroscience, 15, 684557. DOI: 10.3389/fnins.2021.684557
Lutas, A., & Yellen, G. (2021). Kev noj haus ketogenic: metabolic cuam tshuam rau lub hlwb excitability thiab qaug dab peg. Trends in neurosciences, 44(6), 383-394. PIB: 10.1016/j.tins.2021.02.004
Newman, JC, & Verdin, E. (2014). Ketone lub cev raws li kev taw qhia cov metabolites. Trends in endocrinology thiab metabolism, 25(1), 42-52. PIB: 10.1016/j.tem.2013.09.002
Sleiman, SF, Henry, J., Al-Haddad, R., El Hayek, L., Abou Haidar, E., Stringer, T., … & Ninan, I. (2016). Kev tawm dag zog txhawb kev qhia ntawm lub hlwb muab los ntawm neurotrophic factor (BDNF) los ntawm kev ua ntawm ketone lub cev β-hydroxybutyrate. eLife, 5, e15092. DOI: 10.7554/eLife.15092
Yamanashi, T., Iwata, YT, & Shibata, M. (2017). Neurochemical hauv paus hauv qab kev txhim kho ntawm GABAergic kis tau tus mob los ntawm β-hydroxybutyrate hauv nas hippocampus. Neuroscience letters, 643, 35–40. DOI: 10.1016/j.neulet.2017.02.019.
Yudkoff, M., Daikhin, Y., & Nissim, I. (2020). Heterogeneity nyob rau hauv ketone lub cev metabolism hauv kev loj hlob thiab paub tab lub hlwb. Phau ntawv Journal of inherited metabolic disease, 43(1), 30-37. DOI: 10.1002/jimd.12156