β-Hydroxybutyrate - Puas yog BHB ntsev tag nrho tsim sib npaug?
Kwv yees li ntawm lub sijhawm nyeem ntawv: 6 feeb
Muaj peb lub cev ketone tsim los ntawm kev noj zaub mov ketogenic. Cov ketone lub cev yog acetoacetate (AcAc), beta-hydroxybutyrate (BHB), thiab acetone. Acetoacetate yog thawj lub cev ketone tsim los ntawm kev tawg ntawm cov rog hauv daim siab. Ib feem ntawm acetoacetate yog tom qab ntawd hloov mus rau hauv beta-hydroxybutyrate, qhov ntau tshaj thiab ruaj khov ketone lub cev hauv kev ncig.
Txawm hais tias peb lub cev ketone raug tsim los ntawm kev noj zaub mov ketogenic, qhov kev tshaj tawm blog no yog hais txog BHB. Muaj kev txaus siab los tsim ib tus kheej BHB los ntawm kev noj zaub mov ketogenic thiab ntxiv. Ntau tus neeg siv ntau hom exogenous ketones los pab lawv lub hlwb noj qab haus huv.
Cov kev taw qhia ua haujlwm ntawm BHB nthuav dav txuas sab nraud ib puag ncig rau kev tswj hwm cov noob caj ces thiab kev ua haujlwm ntawm tes, thiab lawv cov kev ua yuav cuam tshuam rau ntau yam kab mob tib neeg thiab tib neeg kev laus.
Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: ib qho kev taw qhia metabolite. Kev soj ntsuam txhua xyoo ntawm cov khoom noj khoom haus, 37, 51-76. https://www.annualreviews.org/doi/10.1146/annurev-nutr-071816-064916
Tab sis kuv xav kom koj nkag siab tias muaj qee qhov sib txawv hauv BHB cov ntawv muaj.
D-BHB (D-beta-hydroxybutyrate) thiab L-BHB (L-beta-hydroxybutyrate) yog ob hom ketone lub cev beta-hydroxybutyrate, thiab lawv yog stereoisomers tiag tiag. Hauv cov ntsiab lus yooj yim, lawv yog cov molecules uas qhia tib yam tshuaj mis thiab cov qauv tab sis muaj kev sib txawv ntawm cov atoms hauv qhov chaw, ua rau lawv daim iav duab ntawm ib leeg.
Qhov sib txawv tiag tiag ntawm ob qho no nyob hauv lawv lub luag haujlwm lom neeg thiab kev ua haujlwm hauv lub cev. D-BHB yog daim ntawv ua haujlwm lom neeg, txhais tau tias nws yog ib qho tseem ceeb hauv kev tsim hluav taws xob thiab cov metabolism.
Thaum koj ua raws li kev noj zaub mov ketogenic lossis yoo mov, koj lub siab tsim D-BHB ua lub cev ketone lub cev. Nws ua raws li lwm lub zog rau koj lub hlwb, lub plawv, thiab cov leeg thaum cov piam thaj tsis txaus. D-BHB yog daim ntawv uas tau pom tias muaj ntau yam txiaj ntsig zoo ntawm cov txheej txheem ntawm tes, xws li boosting mitochondrial function, autophagy, thiab mitochondrial biogenesis.
Tag nrho cov no yog qhov tseem ceeb rau lub hlwb noj qab haus huv! Koj tuaj yeem kawm paub ntau ntxiv txog cov txheej txheem mitochondrial ntawm no hauv tsab ntawv blog no kuv tau sau:
Nyob rau hauv sib piv, L-BHB yog ib tug biologically inactive daim ntawv ntawm beta-hydroxybutyrate. Nws yog tsim nyob rau hauv me me nyob rau hauv lub cev thiab muaj tsawg metabolic zog. Txawm li cas los xij, nws tsim nyog sau cia tias kev tshawb fawb tsis ntev los no tau pib nthuav tawm lub luag haujlwm muaj peev xwm rau L-BHB hauv cov txheej txheem ntawm tes sib txawv.
L-BHB hloov mus rau D-BHB li cas?
Hauv tib neeg lub cev, kev hloov pauv ntawm L-BHB rau D-BHB tshwm sim los ntawm cov txheej txheem hu ua stereoisomerization. Nyob rau hauv lub ntiaj teb molecular, stereoisomerization yog tus txheej txheem uas ib tug molecule hloov nws peb-dimensional kev npaj ntawm atoms, converting ib stereoisomer mus rau lwm yam tsis hloov tag nrho cov qauv molecular. Qhov kev hloov pauv ntawm qhov chaw nyob ntawm qhov chaw tuaj yeem ua rau muaj qhov sib txawv ntawm cov khoom thiab kev ua haujlwm ntawm cov isomers uas tshwm sim. (Yog tias koj muaj lub sijhawm nyuaj pom cov lus piav qhia no, no cov ncej blog yog ib tug yuav tsum-nyeem ntawv, raws li nws muaj ib co zoo graphics tsim los ntawm super ntse neeg).
Hauv lub ntiaj teb ntawm BHB, kev hloov pauv tau yooj yim los ntawm ib qho enzyme hu ua beta-hydroxybutyrate dehydrogenase (BDH1), uas muaj nyob hauv mitochondria ntawm cov hlwb, feem ntau hauv daim siab.
Lub enzyme BDH1 catalyzes reversible interconversion ntawm ob stereoisomers, L-BHB thiab D-BHB. Cov tshuaj tiv thaiv kuj suav nrog coenzyme NAD + / NADH. Nyob rau hauv lub xub ntiag ntawm BDH1 thiab NAD +, L-BHB yog oxidized los tsim acetoacetate thaum txo NAD + rau NADH. Tom qab ntawd, acetoacetate tuaj yeem txo qis rov qab mus rau D-BHB, nrog NADH raug oxidized rov qab rau NAD + hauv cov txheej txheem.
Nws tsim nyog sau cia tias cov txheej txheem ntawm kev sib hloov pauv no tsis muaj txiaj ntsig zoo, vim tias L-BHB muaj nyob hauv lub cev hauv ntau qhov me me piv rau D-BHB, thiab cov enzyme BDH1 muaj ntau dua affinity rau D-BHB. Raws li qhov tshwm sim, feem ntau ntawm ketone lub cev siv rau lub zog yog D-BHB, uas yog daim ntawv ua haujlwm lom neeg lub luag haujlwm rau feem ntau ntawm cov txiaj ntsig kev noj qab haus huv cuam tshuam nrog ketosis.
Kev paub tob txog kev ua haujlwm endogenous ntawm BHB, thiab cov cuab yeej txhim kho kom xa BHB lossis rov ua nws cov teebmeem, muab cov lus cog tseg rau kev txhim kho tib neeg kev noj qab haus huv ncua sij hawm thiab kev ua neej ntev.
Newman, John C., thiab Eric Verdin. "Bet-Hydroxybutyrate: ib qho kev taw qhia metabolite." Kev soj ntsuam txhua xyoo ntawm cov khoom noj khoom haus 37 (2017): 51-76. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640868/
Kuv noj BHB yam twg?
Feem ntau cov ketone ntsev nyob rau hauv kev ua lag luam yog sib xyaw ntawm D-BHB thiab L-BHB. Qhov no yog vim tias cov txheej txheem tsim cov ketone ntsev feem ntau ua rau muaj kev sib xyaw ua ke, uas muaj qhov sib npaug ntawm ob lub stereoisomers, D-BHB thiab L-BHB. Cov khoom no qee zaum hu ua "racemic BHB ntsev" lossis tsuas yog "BHB ntsev."
D-BHB yog ketogenic ntau dua thiab muab cov calories tsawg dua li cov sib xyaw sib xyaw ntawm BHB lossis nruab nrab cov saw triglyceride.
Cuenoud, B., Hartweg, M., Godin, JP, Croteau, E., Maltais, M., Castellano, CA, … & Cunnane, SC (2020). Metabolism ntawm exogenous D-beta-hydroxybutyrate, lub zog substrate avidly noj los ntawm lub plawv thiab lub raum. Frontiers hauv Kev Noj Qab Haus Huv, 13. https://doi.org/10.3389/fnut.2020.00013
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias D-BHB yog daim ntawv ua haujlwm lom neeg, uas tau cuam tshuam nrog feem ntau ntawm cov txiaj ntsig kev noj qab haus huv vim yog ketone lub cev, xws li kev txhim kho lub zog metabolism, kev txawj ntse, thiab cov txheej txheem ntawm tes. L-BHB, tsis tshua muaj roj ntsha, tsis pab ntau npaum li cov txiaj ntsig no.
Thaum koj kuaj koj cov ntshav ketones ntawm koj Keto-Moj (txuas txuas), lossis lwm yam khoom siv ntsuas ntshav ketone, koj yuav tsum paub tias lawv tsuas ntsuas D-BHB. Yog li thaum koj haus cov roj ntsha racemic (D / L-BHB) electrolyte ntsev, qhov nce hauv cov ntshav plasma L-BHB mus tsis pom los ntawm koj cov ntshav ketone ntsuas.
Thaum racemic BHB ntsev yog qhov ntau tshaj plaws, qee lub tuam txhab tau pib tsim thiab ua lag luam cov tshuaj ketone tsuas muaj daim ntawv D-BHB, feem ntau hu ua "D-BHB ntsev" lossis "D-BHB esters." Cov khoom lag luam no tsom los muab cov txiaj ntsig ntawm ketone lub cev zoo dua los ntawm kev xa cov khoom siv roj ntsha D-BHB isomer. Txawm li cas los xij, cov tshuaj D-BHB zoo li yuav kim dua piv rau racemic BHB ntsev vim yog cov txheej txheem ntau lawm uas cuam tshuam nrog kev cais D-BHB isomer.
Vim li cas kuv thiaj yuav siv cov ntsev BHB racemic thaum kuv tuaj yeem muaj daim ntawv D-BHB?
Thaum nws los txog rau L-BHB, nws tsuas yog ua ib feem me me - nyob ib ncig ntawm 2-3% - ntawm peb cov BHB tag nrho cov khoom noj thaum yoo mov. Qhov no tau ua rau muaj kev xav tias L-BHB yuav tsis muaj lub luag haujlwm tseem ceeb hauv lub cev. Tab sis kev tshawb fawb tau pib qhia tias L-BHB tab tom ua ntau dua li tsuas yog nyob ib puag ncig tos kom hloov mus rau D-BHB. Nws tau pom tias muaj kev koom tes hauv cov metabolism thiab tuaj yeem muaj lub luag haujlwm dhau los ua ib qho nruab nrab hauv beta-oxidation ntawm cov rog.
Piv txwv li, kev tshawb fawb tsis ntev los no tau siv cov txheej txheem los tshuaj xyuas thiab ntsuas qhov kev faib tawm ntawm L-BHB thiab D-BHB isomers hauv cov ntaub so ntswg sib txawv ntawm cov nas, ob qho tib si ua ntej thiab tom qab kev tswj hwm ntawm racemic ketone ntxiv uas muaj ob isomers. Lawv pom tias ib koob tshuaj ntau ntawm cov tshuaj racemic ketone ntxiv uas muaj L-BHB thiab D-BHB ua rau muaj qhov nce ntxiv hauv L-BHB hauv txhua cov ntaub so ntswg, tshwj xeeb hauv lub hlwb.
Cov kab lis kev cai ntawm tes muab cov lus qhia tias L-BHB muaj txiaj ntsig los txo qhov mob. Thiab nws zoo nkaus li tias muaj L-BHB thiab D-BHB ua ke hauv kev ncig tib lub sijhawm tuaj yeem pab txhawb kev tiv thaiv kab mob.
Kuv yuav tsis ua kom tag nrho L-BHB ua ib qho tsis zoo exogenous ketone ntxiv.
Kev tshawb fawb tseem tab tom ua.
Cov kev tshawb pom no qhia tau tias D- thiab L-BHB muaj qhov sib txawv ntawm kev nqus thiab kev faib tawm thoob plaws cov ntaub so ntswg thiab cov kab mob metabolic sib txawv uas tuaj yeem muaj qhov cuam tshuam tseem ceeb rau kev siv tshuaj kho mob, thiab kev tshawb fawb ntxiv yuav tsum hais txog yuav ua li cas ketones cuam tshuam rau txhua cov ntaub so ntswg sib txawv.
Pereira, D. (2022, Lub Yim Hli 14). Vim li cas peb thiaj xav tau D-BHB thiab L-BHB? KetoNutrition. https://ketonutrition.org/why-do-we-need-both-d-bhb-and-l-bhb/
xaus
Yog tias koj tuaj yeem tau txais koj txhais tes ntawm qee qhov D-BHB, mus tom ntej thiab saib seb koj pom tias nws ua haujlwm zoo rau koj li L-BHB. Tab sis yog tias koj tsis tuaj yeem, lossis koj tsis tuaj yeem them taus daim ntawv bio-zoo tib yam, tsis txhob freak tawm. Kuv siv L-BHB hauv qhov kuv xav tias yog kev sib xyaw ntawm haiv neeg, thiab kuv pom tias nws muaj txiaj ntsig zoo rau kuv lub hlwb. Kuv kuj pom zoo rau cov neeg kuv ua haujlwm nrog. Thiab kuv zoo siab ua raws li cov ntaub ntawv tshawb fawb uas tawm los kom paub ntxiv.
Kuv vam tias koj pom cov ntawv blog no muaj txiaj ntsig hauv kev kawm txhua txoj hauv kev koj tuaj yeem hnov zoo dua!
References
Cuenoud, B., Hartweg, M., Godin, JP, Croteau, E., Maltais, M., Castellano, CA, … & Cunnane, SC (2020). Metabolism ntawm exogenous D-beta-hydroxybutyrate, lub zog substrate avidly noj los ntawm lub plawv thiab lub raum. Frontiers hauv Kev Noj Qab Haus Huv, 13. https://doi.org/10.3389/fnut.2020.00013
Desrochers, SYLVAIN, Dubreuil, PASCAL, Brunet, JULIE, Jette, MANON, David, FRANCE, Landau, BR, & Brunengraber, HENRI (1995). Metabolism ntawm (R, S)-1, 3-butanediol acetoacetate esters, muaj peev xwm parenteral thiab enteral as-ham hauv cov npua nco qab. American Journal of Physiology-Endocrinology thiab Metabolism, 268(4), E660-E667. https://doi.org/10.1152/ajpendo.1995.268.4.E660
Han, YM, Ramprasath, T., & Zou, MH (2020). β-hydroxybutyrate thiab nws cov teebmeem metabolic ntawm cov hnub nyoog txuam nrog pathology. Kev sim & Molecular Tshuaj, 52(4), 548-555. https://doi.org/10.1038/s12276-020-0415-z
Lincoln, BC, Des Rosiers, C., & Brunengraber, H. (1987). Metabolism ntawm S-3-hydroxybutyrate nyob rau hauv perfused nas daim siab. Archives ntawm Biochemistry thiab Biophysics, 259(1), 149-156. https://doi.org/10.1016/0003-9861(87)90480-2
Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: ib qho kev taw qhia metabolite. Kev soj ntsuam txhua xyoo ntawm cov khoom noj khoom haus, 37, 51-76. https://www.annualreviews.org/doi/10.1146/annurev-nutr-071816-064916
Storoschuk, K., & Ari D'Agostino, C. "Vim li cas peb thiaj xav tau D-BHB thiab L-BHB?" Keto Nutrition: Science rau Daim Ntawv Thov. (Lub Yim Hli 14, 2022). https://ketonutrition.org/why-do-we-need-both-d-bhb-and-l-bhb/
Youm, YH, Nguyen, KY, Grant, RW, Goldberg, EL, Bodogai, M., Kim, D., … & Dixit, VD (2015). Cov ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Cov tshuaj noj, 21(3), 263-269. https://www.nature.com/articles/nm.3804
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