Yuav ua li cas yog lub pob khaus no?
Kwv yees li ntawm lub sijhawm nyeem ntawv: 15 feeb
Kab lus no yuav tham txog qee yam hu ua keto pob khaus, uas tuaj yeem tshwm sim hauv qee tus neeg pib noj ketogenic. Peb tab tom yuav tshuaj xyuas qee cov lus qhia nrog kuv los ntawm Marco Medot. Yog tias koj nyob hauv LinkedIn thiab tsis ua raws Marco, cia kuv paub tseeb tias koj ploj lawm. Nws yeej qhia qee cov lus zoo tshaj plaws txog kev noj zaub mov ketogenic, thiab nws muaj kev paub ntau ntawm cov ncauj lus. Nws qhia txog kev tshawb fawb zoo heev, Kuv ua siab ntev ua tsis tau! Tab sis thaum kuv qhia nws tias hauv cov lus ntawm nws cov ntawv LinkedIn, nws qhia kuv kom mus ntxiv! Yog li ntawd peb nyob ntawm no.
Introduction
Ua ntej, cia peb tham txog qhov ua pob liab liab no yog dab tsi. Nws yeej muaj lub npe thiab hu ua Prurigo Pigmentosa (PP).
Nyob rau hauv tsab xov xwm "Prurigo Pigmentosa - Kev Tshawb Fawb Ntau Lub Tsev Kawm Ntawv," luam tawm nyob rau hauv phau ntawv Journal of the American Academy of Dermatology, cov kws tshawb fawb tau ua qhov kev tshuaj xyuas rov qab ntawm 30 tus neeg mob kuaj pom Prurigo Pigmentosa. Txoj kev tshawb no tau qhia tias 40% ntawm cov neeg mob no tau noj ketogenic noj ua ntej pib cov tsos mob, uas feem ntau suav nrog pruritus thiab hyperpigmentation, feem ntau cuam tshuam rau sab nraub qaum thiab hauv siab. Kev kuaj mob histopathological feem ntau pom tias mob me me spongiosis thiab lymphoplasmacytic infiltrate, nrog cov neutrophils thiab eosinophils tsis tshua pom.
Cia peb txhais qee cov ntsiab lus ntawd.
- me me spongiosis - Ib qho o lossis kua dej tsim ntawm cov tawv nqaij hauv txheej txheej ntawm daim tawv nqaij
- lymphoplasmacytic infiltrate - Lub cev tiv thaiv kab mob uas tau sib sau ua ke hauv ib cheeb tsam ntawm cov ntaub so ntswg. Qhov no feem ntau yog cov lus teb rau qee hom kev mob, kab mob, lossis lwm yam kev tiv thaiv kab mob.
- neutrophils - Feem ntau thawj cov kab mob tiv thaiv kab mob tuaj txog ntawm qhov chaw kis kab mob lossis raug mob. Lawv teb sai sai rau cov cim ntawm kev cuam tshuam los ntawm cov kab mob, kab mob, lossis lwm yam kab mob. Ib qho ntawm lawv cov haujlwm tseem ceeb yog phagocytosis, qhov chaw uas lawv nkag mus thiab zom cov kab mob nkag mus.
- eosinophils - Ib feem ntawm lub cev tiv thaiv kab mob thiab koom nrog hauv lub cev tiv thaiv mechanisms. Lawv muaj tsawg dua li lwm hom qe ntshav dawb, zoo li neutrophils, tab sis lawv tseem ceeb hauv kev tiv thaiv kab mob parasitic thiab kev ua xua.
Tsab xov xwm hais ntxiv tias qhov kev kho mob zoo tshaj plaws rau PP tau pom tias yog tshuaj tua kab mob hauv qhov ncauj, uas ua rau muaj kev daws teeb meem tag nrho hauv cov neeg mob kho, qhov tshuaj pleev corticosteroids tsuas yog muab kev pab ib ntus xwb. Nws tau hais txog ntau yam kev tshwm sim thiab kev nthuav qhia ntawm PP, qhia txog nws qhov kev nthuav dav thoob plaws hnub nyoog thiab poj niam txiv neej, nrog rau poj niam tseem ceeb tshaj plaws. Thiab nws taw qhia tias tsis yog txhua qhov xwm txheej cuam tshuam nrog kev noj zaub mov ketogenic.
Tab sis tsis yog qhov nthuav tias muaj kev ua haujlwm hnyav heev hauv lub cev tiv thaiv kab mob? Nco ntsoov ntawm qhov ntawd, vim kuv yuav qhia qhov kev xav ib puag ncig uas yog ib feem ntawm tsab xov xwm no. Nco ntsoov nyeem!
Cov ntaub ntawv kawm 1
Hauv tsab xov xwm "Prurigo Pigmentosa Tom Qab Keto Diet thiab Bariatric Surgery," ib qho kev tshawb fawb tau nthuav tawm ntawm tus poj niam hnub nyoog 25 xyoo uas tsim cov tawv nqaij hu ua Prurigo Pigmentosa (PP) tom qab kev phais plab plab thiab ua raws li kev noj haus ketogenic. . Tus mob no, tus cwj pwm los ntawm cov pob liab liab uas pib ua papules me me thiab nce mus rau cov plaques loj, tsis yog ib qho ntawm cov tib neeg ntawm kev noj zaub mov ketogenic. Qhov zoo siab, tus neeg mob yav dhau los tau ntsib cov pob khaus zoo sib xws thaum sim ua ntej ntawm kev noj zaub mov ketogenic. Hauv ob qho xwm txheej, cov pob khaus tau zoo tuaj thaum nws rov qhia cov carbohydrates rau hauv nws cov zaub mov. Tom qab kev phais, cov pob khaus pib txhim kho nrog kev siv ntawm qhov ncauj minocycline, ib hom tshuaj tua kab mob, thiab kev noj zaub mov ntau ntxiv, tab sis nws tsis tau ploj mus kom txog thaum nws muaj kev noj zaub mov ntau dua carbohydrate. Cov ntaub ntawv no qhia txog qhov muaj peev xwm sib txuas ntawm kev hloov pauv kev noj haus, tshwj xeeb yog cov uas ua rau ketosis, thiab kev txhim kho ntawm PP, thaum tseem hais txog qhov ua tau zoo ntawm kev noj haus hauv kev kho mob. Cov pob khaus feem ntau tau tshem tawm dhau ib lub hlis ib zaug, kev noj zaub mov nplua nuj carbohydrate tau rov pib dua.
Qhov kev nthuav qhia no tuaj yeem qhia txog ib
Alkhouri, F., Alkhouri, S., & Potts, GA (2022). Prurigo Pigmentosa Tom Qab Keto Noj Qab Haus Huv thiab Bariatric Surgery. Cureus, 14(4), e24307. https://doi.org/10.7759/cureus.24307
kev sib raug zoo ntawm PP thiab lub xeev metabolic ntawm lub cev.
Cov ntaub ntawv kawm 2
tsab xov xwm "Kev tso cai ntawm Prurigo Pigmentosa tom qab tawg Ketogenic noj zaub mov thiab rov pib noj zaub mov tsis tu ncua," nws yog qhov tseeb tias tus neeg mob, tus poj niam hnub nyoog 21 xyoos, tau qhia tiag tiag kom tsis txhob noj ketogenic noj thiab noj minocycline rau nws Prurigo Pigmentosa (PP) . Txawm li cas los xij, nws tau xaiv rov pib noj zaub mov tsis tu ncua yam tsis noj tshuaj. Tom qab qhov kev hloov pauv no hauv nws txoj kev noj haus, nws cov kab mob ntawm daim tawv nqaij tau daws nyob rau hauv ob lub hlis, tsuas yog lub teeb-xim av tom qab inflammatory pigmentation. Tsis muaj kev rov tshwm sim ntawm PP tom qab 12 lub hlis ntawm kev soj ntsuam txij li thaum nws rov qab noj cov zaub mov carbohydrate ntau dua. Cov ntaub ntawv no qhia txog lub peev xwm rau kev hloov pauv kev noj haus ib leeg kom ua tau zoo hauv kev daws PP, tshwj xeeb tshaj yog thaum cuam tshuam nrog kev noj zaub mov ketogenic.
Lwm tus poj niam muaj hnub nyoog 21 xyoo noj qab haus huv
Daneshpazhooh, M., Nikyar, Z., Kamyab Hesari, K., Rostami, E., Taraz Jamshidi, S., & Mohaghegh, F. (2022). Kev tshem tawm ntawm prurigo pigmentosa tom qab rhuav tshem cov khoom noj ketogenic thiab rov pib noj cov zaub mov tsis tu ncua. Advanced Biomedical Research, 11, 70. https://doi.org/10.4103/abr.abr_138_21
nthuav tawm nrog khaus ntawm daim tawv nqaij
lub hauv siab thiab caj dab evolving rau 2 lub lis piam.
Cov pob khaus tshwm sim 1 lub lis piam tom qab pib ib
carbohydrate txwv KD.
Cov ntaub ntawv kawm 3
Nyob rau hauv rooj plaub tsab ntawv ceeb toom hu ua 'Prurigo Pigmentosa Post-Bariatric Surgery,' ib tug 25-xyoo-laus Saudi txiv neej tus neeg mob tau ntsib ib tug tshwj xeeb piv txwv ntawm Prurigo Pigmentosa tom qab phais bariatric, diverging los ntawm tus mob tus yam ntxwv pej xeem. Tshwj xeeb tshaj yog, 18 hnub tom qab kev phais, nws tsim ib qho pruritic, erythematous pob tawm ntawm nws lub cev, lub plab mog, thiab hauv siab. Pathological tshawb pom los ntawm daim tawv nqaij biopsies qhia ib tug focal interface cov tshuaj tiv thaiv, tawg ntho necrotic keratinocytes, dilated plaub hau follicles uas muaj cov kab mob, thiab ib tug me me acanthotic dermis nrog perivascular lymphocytes, eosinophils, thiab extravasated cov ntshav liab. Cov kev tshawb pom no qhia txog kev kho lub cev tiv thaiv kab mob, nrog rau lub cev tiv thaiv kab mob uas muaj peev xwm tsom mus rau cov teeb meem yav dhau los tsis tau daws hauv daim tawv nqaij. Tus neeg mob cov pob khaus tau daws tag nrho hauv ob lub lis piam ntawm kev kho mob nrog tshuaj pleev thiab qhov ncauj, txawm hais tias tom qab mob hyperpigmentation tshwm sim. Cov ntaub ntawv no qhia txog lub peev xwm rau PP kom pom tseeb hauv ntau haiv neeg thiab cov xwm txheej, thiab qhia txog lub luag haujlwm ntawm lub cev tiv thaiv kab mob hauv kev teb rau kev hloov pauv hauv lub cev metabolic.
Niaj hnub no, cov neeg mob Prurigo pigmentosa (PP) tau raug tshaj tawm los ntawm thoob plaws lub ntiaj teb, suav nrog cov neeg mob PP uas tshwm sim tom qab phais bariatric rau kev poob phaus yam tsis muaj kev hloov pauv kev noj haus ketogenic.
Jazzar, Y., Shadid, AM, Beidas, T., Aldosari, BM, & Alhumidi, A. (2023). Prurigo pigmentosa post-bariatric phais: cov ntaub ntawv qhia. AME Case Reports, 7, 43. https://dx.doi.org/10.21037/acr-23-45
Cov ntaub ntawv kawm 4
Hauv txoj kev tshawb fawb "Ketogenic Diet-induced Prurigo Pigmentosa ("Keto Rash"): Ib Daim Ntawv Qhia Txog Cov Ntaub Ntawv thiab Cov Ntaub Ntawv Tshawb Xyuas," luam tawm nyob rau hauv Phau ntawv Journal of Clinical and Aesthetic Dermatology, 21-xyoo-laus Hispanic txiv neej tau ntsib ib qho teeb meem dermatological tom qab. ua raws li kev noj haus ketogenic. Nws tsim Prurigo Pigmentosa (PP), tus cwj pwm los ntawm cov pob khaus khaus ntawm nws lub hauv siab thiab sab nraub qaum, uas ua rau peb lub lis piam. Cov pob khaus tshwm tom qab ob lub hlis ntawm kev noj zaub mov, thaum nws poob 20 phaus. Kev soj ntsuam kuaj pom erythematous rau hyperpigmented papules coalescing rau hauv reticulated nyias plaques. Daim tawv nqaij biopsy tau lees paub qhov kev kuaj mob ntawm PP, qhia spongiosis thiab ib qho perivascular infiltrate ntawm eosinophils, lymphocytes, thiab tsawg neutrophils. Tus neeg mob txoj kev kho mob koom nrog qhov ncauj doxycycline thiab txiav tawm ntawm kev noj zaub mov ketogenic, ua rau muaj kev daws teeb meem ntawm pruritus hauv ob lub lis piam thiab maj mam hloov ntawm cov erythematous plaques rau hauv asymptomatic, hyperpigmented thaj ua rau thaj. Cov ntaub ntawv no qhia txog cov teeb meem ntawm daim tawv nqaij cuam tshuam nrog kev hloov pauv kev noj haus, tshwj xeeb tshaj yog cov khoom noj ketogenic thiab nws lub luag haujlwm hauv kev ua rau PP.
Cov kws kho mob dermatologist yuav tsum tshuaj xyuas kev noj zaub mov ntawm txhua tus neeg mob nrog
Xiao, A., Kopelman, H., Shitabata, P., & Nami, N. (2021). Ketogenic Diet-induced Prurigo Pigmentosa ("Keto Rash"): Ib Daim Ntawv Qhia Txog Cov Ntaub Ntawv thiab Phau Ntawv Ntsuam Xyuas. Phau ntawv Journal of Clinical and Aesthetic Dermatology, 14(12Suppl 1), S29–S32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903224/
ib tug pruritic erythematous papular reticulated
pob khaus ntawm lub cev, thiab xav txog Prurigo Pigmentosa (PP) nyob rau saum toj
Ntawm lawv qhov sib txawv rau txhua tus neeg mob nthuav tawm nrog kev tawm tsam ntawm daim tawv nqaij tom qab pib noj ketogenic.
Cov ntaub ntawv kawm 5
Hauv cov ntaub ntawv kawm hu ua 'Ib Yam Tsis Muaj Prurigo Pigmentosa nyob rau hauv ib khub niam txiv Danish,' ob tus kwv tij Danish noj qab haus huv, hnub nyoog 16 thiab 18, tsim PP kwv yees li ob lub lis piam tom qab pib noj ketogenic. Kev kuaj mob histopathological ntawm lawv daim tawv nqaij qhia txawv cov yam ntxwv. Tus neeg muaj hnub nyoog 18 xyoo txoj kev kuaj ntshav pom tau tias muaj kev sib kis, spongiosis, thiab focal lichenoid hloov nrog feem ntau eosinophilic thiab qee qhov neutrophil granulocytes hauv dermis. Tus neeg muaj hnub nyoog 16 xyoo qhov kev kuaj pom pom me me hyperkeratosis, me me epidermal hyperplasia nrog ob peb necrotic keratinocytes, thiab ib qho me me dermal infiltrate ntawm lymphocytes thiab melanophages. Cov kev tshawb pom no qhia txog cov kev hloov pauv dermatological cuam tshuam nrog PP, tshwj xeeb hauv cov ntsiab lus ntawm kev noj zaub mov ketogenic.
Cia kuv piav qhia meej txog qhov kev kuaj ntshav pom. Lawv pom crusty, hauv zos pob, thiab qee zaum khaus tawv nqaij uas tuav cov kua dej ntau dua li qhov nws yuav tsum tau vim yog mob. Thiab thaum lawv saib seb hom cell twg thiab cov kev hloov pauv tau ua rau qhov no, lawv pom, zoo li hauv lwm qhov kev tshawb fawb, neutrophils thiab eosinophils. Qhia tias lub cev tau hnov mob rau ib yam dab tsi cuam tshuam nrog cov pob liab liab.
Feem ntau cov neeg mob uas muaj PP tsis muaj ketosis lossis ntshav qab zib, thiab peb cov ntaub ntawv nug seb puas muaj qee yam ntaub so ntswg (xws li, HLA hom) txawm li cas los xij muaj qhov sib txawv rau ketone lub cev hauv cov ntshav thiab yog li muaj feem ntau ntawm kev tsim PP.
Danielsen, M., Pallesen, K., Riber-Hansen, R., & Bregnhøj, A. (2023). Ib qho tsis tshua muaj tshwm sim ntawm Prurigo Pigmentosa hauv ib khub niam txiv Danish. Case Reports in Dermatology, 15, 26–30. https://doi.org/10.1159/000528422
Yog li, dab tsi heck mus ntawm no? kuv tsis paub. Kuv tsis yog ib hom kev tiv thaiv kab mob. Tab sis kuv muaj ib qho kev nkag siab zoo uas yuav cia siab tias yuav ua rau cov lus teb zoo sib xws uas qee tus neeg yuav tsum tau noj ketogenic.
Qhov sib txawv ntawm qhov sib txawv ntawm Ketogenic noj zaub mov thiab kev tiv thaiv kab mob
Yog li txhua tus paub, ntawm lub sijhawm no, tias kev noj zaub mov ketogenic yog cov rog rog, nruab nrab cov protein, thiab qis-carbohydrate txoj kev noj zaub mov uas pib thiab tswj kev hloov pauv hauv cov metabolism hauv tib neeg lub cev, ua rau lub xeev ntawm ketosis.
Yog tias koj ua raws li qhov blog no tag nrho, koj paub tias lub xeev no, tus cwj pwm los ntawm kev nce qib ntawm ketone lub cev xws li β-hydroxybutyrate (BHB), acetoacetate, thiab acetone, tsis yog ib qho kev hloov pauv rau cov piam thaj hauv lub zog; Nws sawv cev rau ib qho tseem ceeb reprogramming ntawm cellular thiab systemic functions. Muaj ntau cov ntawv hauv blog no tham txog cov teebmeem ntawm lub hlwb lub cev tiv thaiv kab mob thiab yuav ua li cas hloov kho neuroinflammation.
Tab sis vim tias qhov blog no feem ntau tsom rau koj cov noggin, peb yeej tsis tau nkag mus rau qhov cuam tshuam deb ntawm kev noj haus ketogenic rau lub cev tiv thaiv kab mob feem ntau.
Hauv qib cellular, ketone lub cev, tshwj xeeb tshaj yog BHB, siv cov kev tswj hwm ntawm txoj hauv kev tiv thaiv kab mob tseem ceeb. BHB paub tias inhibit NLRP3 inflammasome, multiprotein complex nyob rau hauv neutrophils uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob hauv lub cev thiab mob. NLRP3 inflammasome qhov ua rau ua rau tso tawm cov cytokines pro-inflammatory, xws li IL-1β thiab IL-18, uas yog ib qho tseem ceeb hauv kev tiv thaiv kab mob tab sis kuj tuaj yeem ua rau muaj kab mob. Los ntawm kev hloov kho cov haujlwm ntawm NLRP3 inflammasome, BHB tuaj yeem txo qis cov lus teb ntau dhau, qhia txog kev sib npaug ntawm lub cev tiv thaiv kab mob.
Tsis tas li ntawd, kev noj zaub mov ketogenic cuam tshuam txuas mus rau lub plab microbiome, ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob. Lub plab microbiota yog ib qho kev ecosystem uas cuam tshuam rau kev tiv thaiv kab mob. Kev hloov pauv kev noj haus muaj txiaj ntsig cuam tshuam rau kev muaj pes tsawg leeg thiab kev ua haujlwm ntawm microbiome, yog li hloov lub cev tiv thaiv kab mob. Kev noj zaub mov ketogenic tuaj yeem ua rau lub plab microbiota uas nyiam cov tshuaj tiv thaiv kab mob, ua kom lub cev muaj peev xwm tswj tau cov kab mob autoimmune thiab cov lus teb inflammatory.
β-HB tswj kev ua haujlwm ntawm NLRP3 inflammasome hauv neutrophils thiab macrophages. Lub trajectory ntawm caspase-1 yog qhov tseem ceeb rau kev sib cais ntawm precursors ntawm ntau cov proteins thiab yog ib qho tseem ceeb hauv kev tiv thaiv kab mob. K + efflux tiv thaiv uas tshwm sim los ntawm β-HB inhibits qhov ua kom NLRP3 inflammasome. Ketone lub cev qhib HCA2 receptors thiab inhibit qhov sib dhos ntawm NLRP3 inflammasome.
Ansari, MS, Bhat, AR, Wani, NA, & Rizwan, A. (2022). Antiepileptic Mechanisms ntawm Ketogenic noj zaub mov. Tam sim no Neuropharmacology, 20(11), 2047-2060. PIB: 10.2174X1570159
Tab sis dab tsi tshwm sim nyob rau hauv cov pob khaus no? Tsis yog kev noj zaub mov ketogenic yuav tsum txo qis cov lus teb? Yog lawm! Tab sis…
Nyob rau hauv cov ntsiab lus ntawm daim tawv nqaij noj qab haus huv thiab tej yam kev mob zoo li Prurigo Pigmentosa (PP), ketogenic noj cov tshuaj immunomodulatory los ua tshwj xeeb. Cov tawv nqaij, lub cev tiv thaiv kab mob, yog lub tsev rau ntau lub cev tiv thaiv kab mob, suav nrog neutrophils thiab eosinophils. Cov hlwb no yog ib qho tseem ceeb rau lub cev tiv thaiv kab mob hauv lub cev, ua thawj tus neeg teb rau kev kis kab mob thiab mob. Hauv PP, kev nkag mus ntawm neutrophils thiab eosinophils rau ntawm daim tawv nqaij yog qhov qhia txog kev tiv thaiv kab mob. Kev noj zaub mov ketogenic, los ntawm nws cov teebmeem hauv lub cev thiab hauv zos, tuaj yeem cuam tshuam cov lus teb no. Los ntawm kev hloov lub cev tiv thaiv kab mob hauv lub cev thiab hloov kho txoj hauv kev inflammatory, kev noj zaub mov tuaj yeem ua rau muaj kev txhim kho lossis rov ua kom muaj kev tiv thaiv kab mob hauv daim tawv nqaij.
Kuv yuav mus qhov twg qhov kev xav txo hwj chim no? Yog vim li cas cov ntaub ntawv scientific, tau kawg. Qhov kev xav no tau txhawb ntxiv los ntawm kev tshawb fawb txog kev noj zaub mov ketogenic hauv lwm cov ntsiab lus, xws li kev kho mob qog noj ntshav. Kev tshawb fawb qog noj ntshav tau qhia tias kev noj zaub mov ketogenic tuaj yeem cuam tshuam cov qog loj hlob thiab kev tiv thaiv kab mob. Thaum cov txheej txheem yog complex thiab multifaceted, ib tug nam yog lub modulation ntawm lub cev tiv thaiv kab mob, pab txhawb lub cev lub peev xwm los tsom thiab rhuav tshem cov qog nqaij hlav cancer. Qhov no qhia tau hais tias kev noj zaub mov ketogenic muaj peev xwm ua rau muaj kev cuam tshuam rau lub cev tiv thaiv kab mob, tsis yog hauv kev mob qog noj ntshav, tab sis nyob rau lwm yam mob uas lub cev tiv thaiv kab mob tseem ceeb heev.
Lwm yam dab tsi yuav tshwm sim? Zoo, kuv tsis paub! Tab sis raws li qhov kuv nkag siab txog kev noj zaub mov ketogenic thiab kev tiv thaiv kab mob? Kuv twv qee qhov ntawm no!
Hypothesis: Ketogenic noj zaub mov thiab Immune System Modulation
Kev ua haujlwm ntawm metabolic thiab kev tiv thaiv kab mob
Cia peb mus los ntawm qee cov txheej txheem uas tuaj yeem koom nrog hauv kev tiv thaiv kab mob ntxiv uas peb pom nrog Keto Rash.
Metabolic hloov pauv tseem ceeb hauv kev tiv thaiv kab mob
Kev noj haus ketogenic ua rau muaj kev hloov pauv ntawm cov piam thaj mus rau ketone lub cev rau lub zog. Qhov kev hloov pauv no tuaj yeem cuam tshuam rau lub cev tiv thaiv kab mob, vim qhov sib txawv ntawm lub zog tuaj yeem hloov kho lawv txoj haujlwm. Piv txwv li, ketone lub cev tuaj yeem hloov qhov ua kom thiab ua haujlwm ntawm lub cev tiv thaiv kab mob xws li neutrophils thiab eosinophils, uas feem ntau pom hauv PP qhov txhab. Ketone lub cev tau pom tias inhibit NLRP3 inflammasome, ib feem ntawm lub cev tiv thaiv kab mob koom nrog kev mob. Qhov no tuaj yeem txo qhov mob ntev tab sis kuj tseem tuaj yeem txhim kho lub cev cov lus teb rau cov kev ntxhov siab, xws li cov kab mob lossis cov hlwb puas.
β-HB tswj kev ua haujlwm ntawm NLRP3 inflammasome hauv neutrophils thiab macrophages
Kumar, A., Kumari, S., & Singh, D. (2022). Kev nkag siab rau hauv Cellular Interactions thiab Molecular Mechanisms of Ketogenic Diet for Comprehensive Management of Epilepsy. Cov duab, 2022120395. https://doi.org/10.20944/preprints202212.0395.v1
Lub plab Microbiome thiab Immune Response
Kev noj zaub mov ketogenic tau hloov pauv lub plab microbiome. Txij li feem ntau ntawm lub cev tiv thaiv kab mob nyob rau hauv lub plab, kev hloov hauv microbiome muaj pes tsawg leeg tuaj yeem muaj txiaj ntsig zoo rau kev tiv thaiv kab mob.
Lub plab hnyuv microbiome, feem ntau cuam tshuam nrog kev noj zaub mov ketogenic, tuaj yeem txhim kho lub cev muaj peev xwm tiv thaiv kab mob thiab tuaj yeem piav qhia txog kev tiv thaiv kab mob hauv daim tawv nqaij.
Txo qhov mob
Kev noj zaub mov ketogenic paub tias txo cov kab mob hauv lub cev. Qhov kev txo qis no tuaj yeem ua rau lub cev tiv thaiv kab mob ua kom pom tseeb dua ntawm cov teeb meem hauv zos, xws li cov tawv nqaij mob hauv PP. Kev txo qis hauv cov kab mob hauv lub cev tuaj yeem "unmask" yav dhau los subclinical tej yam kev mob, ua rau muaj kev nce ntxiv hauv kev tiv thaiv kab mob hauv qee qhov chaw xws li daim tawv nqaij.
Oxidative Stress thiab Immune Surveillance
Nws yog qhov paub zoo tiag tiag hauv cov ntaub ntawv tshawb fawb, tias cov khoom noj ketogenic tuaj yeem cuam tshuam oxidative kev ntxhov siab hauv lub cev. Qhov sib npaug ntawm oxidative kev nyuaj siab yog qhov tseem ceeb rau kev pom kev tiv thaiv kab mob. Kev txo qis oxidative kev ntxhov siab tuaj yeem txhim kho kev tiv thaiv kab mob, tso cai rau lub cev tiv thaiv kab mob kom paub zoo dua thiab teb rau cov kab mob lossis cov hlwb txawv txav, uas tuaj yeem pom hauv daim tawv nqaij ntawm PP.
Hormonal thiab Cytokine Hloov
Kev noj zaub mov ketogenic tuaj yeem hloov pauv cov tshuaj hormones thiab cytokine ntau lawm. Cov kev hloov pauv no tuaj yeem muaj ntau yam cuam tshuam rau lub cev tiv thaiv kab mob, muaj peev xwm txhim kho nws qhov kev ua haujlwm lossis hloov nws lub hom phiaj. Piv txwv li, kev hloov pauv ntawm cov tshuaj insulin thiab kev loj hlob zoo li insulin tuaj yeem cuam tshuam kev mob thiab kev ua haujlwm ntawm lub cev.
Yog li, kuv txo hwj chim tso tawm qhov kev xav tias kev noj zaub mov ketogenic cuam tshuam rau cov metabolism, lub plab microbiome, o, oxidative kev nyuaj siab, thiab hormonal tshuav nyiaj li cas tuaj yeem sib sau ua ke ntawm kev tiv thaiv kab mob. Qhov kev hloov kho no tuaj yeem tshwm sim raws li kev txhim kho lossis ntau lub hom phiaj tiv thaiv kab mob hauv cov xwm txheej tshwj xeeb xws li PP, qhov uas peb pom kev nce hauv cov hlwb xws li neutrophils thiab eosinophils hauv daim tawv nqaij.
xaus
Tsis muaj qhov no ua rau kuv ntshai. Nws suab zoo li txoj cai ntawm qhov tsis ncaj ncees lawm. Tsis yog ib qho cuam tshuam, tab sis ib qho kev rov qab los ntawm kev tiv thaiv kab mob. Tsis yog ib lub tswb, tab sis ib tug recalibration ntawm kev tiv thaiv kab mob. Thiab yeej tsis yog qhov xwm txheej pathological uas yuav tsum tau siv tshuaj tua kab mob lossis kev tuag ntawm kev noj zaub mov uas muab kev kho mob metabolic rau tus neeg mob.
Hauv kev xaus, kev noj zaub mov ketogenic sawv cev rau kev cuam tshuam tseem ceeb hauv tib neeg cov metabolism nrog cuam tshuam rau lub cev tiv thaiv kab mob. Nws lub peev xwm los hloov kho txoj hauv kev tiv thaiv kab mob tseem ceeb, hloov lub plab microbiome, thiab cuam tshuam rau lub cev thiab lub cev tiv thaiv kab mob hauv zos qhia tias muaj peev xwm ua rau lub cev tiv thaiv kab mob zoo dua qub hauv cov xwm txheej zoo li PP. Qhov no txhim kho lossis rov ua kom lub cev tsis muaj zog tuaj yeem yog qhov kev xav ntawm lub cev hloov mus rau lub xeev metabolic tshiab, nrog rau kev cuam tshuam rau ntau yam kev noj qab haus huv, suav nrog kev mob ntawm daim tawv nqaij, kab mob autoimmune, thiab txawm tias mob qog noj ntshav.
Hauv kuv txoj haujlwm nrog cov neeg mob, kuv tsis tau muaj ib tus neeg uas qhov pob khaus no tsis ploj mus nrog kev ua siab ntev thiab, tej zaum, kev hloov qeeb qeeb hauv kev noj cov carbohydrates. Kuv yeej tsis tau, hauv kuv lub peev xwm ua tus kws qhia kev noj qab haus huv, tau hais kom leej twg nrhiav tshuaj tua kab mob. Vim kuv qhov kev kuaj mob, kuv twb paub lawm tias cov tshuaj tiv thaiv kab mob thiab cortisol cream lossis gels yuav tsis ua kom yuam kev. Kuv hais rau kuv cov neeg mob tias qhov pob khaus no yuav yog ib qho kev qhia zoo tias lawv lub cev tiv thaiv kab mob rov qab los yog txhawb nqa. Kuv paub tias kuv tau tawm thiab nyob rau ntau lub hlis thaum kuv hloov mus rau hauv kuv cov khoom noj ketogenic. Qee lub sij hawm nws khaus khaus heev thiab tsis xis nyob, tab sis nws thiaj li ploj mus. Thiab kuv shudder xav yog tias kuv yuav tau freaked tawm thiab tawm ntawm kuv cov zaub mov ketogenic raws li cov lus teb rau nws, vim kuv paub tseeb tias koj, kuv lub hlwb yuav tsis ua hauj lwm zoo li niaj hnub no thiaj li yuav sau koj cov lus no.
Kuv tsis nyob hauv koj lub cev khaus, keto-pob liab. Yog li, yam koj ua thiab koj xaiv teb li cas yog nyob ntawm koj. Tsis muaj kev txiav txim rau kuv, kuv lees tias koj. Kuv xav kom koj zoo siab.
Tab sis kuv xav kom koj paub tias muaj peev xwm piav qhia txog qhov tshwm sim uas tsis yog "cov lus teb pathological" raws li tus kws kho mob dermatologist nruab nrab lossis tsis yog-ketogenic kawm MD lossis tus kws kho mob ua haujlwm tuaj yeem hais lossis xav. Yog tias nws nyuaj rau koj, nce mus rau hauv koj cov carbs txog 5 lossis 10 grams thiab ua haujlwm nrog koj tus kws kho mob lossis tus kws noj zaub mov. Saib seb qhov ntawd ua li cas. Tab sis nws tseem yuav tshwm sim rau qee qhov thaum koj tau txais qis carb txaus uas cov khawv koob metabolic pib tshwm sim.
Nov yog yam tshuaj niaj hnub tsis qhia rau koj. Vim tias nws tau tsom mus rau kev tswj cov tsos mob es tsis yog cov hauv paus hauv paus kho, kuv tsis xav tias nws paub. Tab sis kev kho mob yog ntxhov. Nws tsis xis nyob. Tab sis nws yog neeg txawj ntse. Koj lub cev zoo li yuav muab tej yam kom raug thiab hloov kho hauv txoj hauv kev uas koj thiab / lossis koj tus kws kho mob, lossis txawm tias kuv tus kheej yog ib tus neeg nyiam tshaj plaws hauv cov ncauj lus no, tsis tuaj yeem pib nkag siab.
Kuv txhawb kom koj nthuav qhov koj txaus siab tshawb nrhiav thiab ua siab ntev hauv koj lub hom phiaj ntawm kev kho mob. Txuas ntxiv mus yog tias koj ua tau. Thiab saib dab tsi ua tau rau koj.
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