Introduction
Kuv yog tus qab heev hauv kev sau tsab xov xwm no. Ua kom ncaj ncees, kuv tau zam kev sau ntawv txog kev siv cov khoom noj ketogenic nrog kev noj zaub mov tsis zoo kiag li. Kuv tsis xav nrog qhov kuv xav tias yuav yog qhov rov qab los ntawm lub zej zog kev puas siab puas ntsws, uas muaj kev ntseeg ruaj khov tias txhua yam kev txwv ntawm kev xaiv zaub mov yuav ua rau muaj cov tsos mob hnyav dua lossis muaj lub zog los tsim kev noj mov. teeb meem txhua yam ntawm nws tus kheej.
Tab sis tom qab ntawd nws tshwm sim rau kuv tias tej zaum tib neeg yuav xav tias vim lawv tsis pom kev noj zaub mov tsis zoo nrog rau ntawm qhov chaw no, kev noj zaub mov ketogenic yuav tsum tsis txhob suav tias yog kev kho mob. Los yog qhov ntawd, qee qhov, tsis muaj pov thawj txaus los txhawb nws txoj kev siv.
Thiab qhov ntawd tsuas yog tsis yog qhov tseeb xwb.
Yog li, hauv tsab xov xwm no, kuv yuav txwv tsis pub cov neeg nyeem uas tuaj yeem tsis tuaj yeem tuaj rau qhov kev xav ntawd. Tab sis qhov kuv yuav tsis ua yog mus rau hauv lub ntsiab lus ntawm Binge Eating Disorder (BED) lossis muab koj cov ntaub ntawv txheeb cais txog nws qhov kev nthuav dav. Muaj ntau cov ntawv blog uas muab cov kev pabcuam ntawd. Kuv yuav xav tias yog tias koj nrhiav los yog tuaj hla kab lus no, koj lossis ib tus neeg koj hlub twb tau kuaj pom lossis pom tias muaj kev txom nyem los ntawm hom kev noj zaub mov no. Thiab hais tias koj nyob ntawm no rau kev sib tham ncaj qha txog yuav ua li cas cov zaub mov ketogenic tuaj yeem ua lub luag haujlwm hauv kev rov qab los thiab, yog tias muaj, yuav ua li cas nws tuaj yeem hloov kho qee yam ntawm cov txheej txheem pathological peb pom hauv qhov teeb meem no.
Thaum kawg ntawm tsab xov xwm no, koj yuav nkag siab tias vim li cas cov zaub mov ketogenic yuav tsum tsis yog tsuas yog suav tias yog kev kho mob zoo rau Binge Eating Disorder (BED) tab sis yuav tsum tau muab ua ib feem ntawm tus qauv kev saib xyuas. Kuv thov txim yog tias cov lus ntawd tsis txaus ntseeg thiab ua rau koj lub tswv yim tam sim no hais txog yuav ua li cas cov khoom no ua rau muaj kev pheej hmoo.
Tab sis qhov tseeb, nws tsuas yog science xwb.
Kev Tshawb Fawb Tom Qab BED thiab Ketogenic Noj Qab Haus Huv
Lub hlwb Hypometabolism hauv BED
Neurons yog cov kab mob metabolic heev thiab cov hlwb uas xav tau lub zog tas li. Hauv cov xeev ntawm lub paj hlwb hypometabolism qhov ua tau zoo ntawm cov piam thaj nce ntxiv thiab kev siv los ntawm cov neurons raug cuam tshuam, ua rau muaj zog tsis txaus. Lub paj hlwb hypometabolism yog lub xeev ntawm kev txo qis hauv cov metabolism hauv lub hlwb, thiab ntau qhov kev tsis sib haum xeeb tau pom tias muaj qhov no raws li cov txheej txheem hauv qab no.
Peb paub qhov no li cas? Vim tias qhov txo qis hauv cov metabolism tuaj yeem raug kuaj pom siv cov txheej txheem kho mob xws li positron emission tomography (PET) scans, uas qhia txog thaj chaw ntawm lub hlwb uas tsis muaj zog hauv kev siv cov piam thaj. Qhov kev txo qis uas pom feem ntau cuam tshuam nrog qis qis ntawm cov piam thaj nce ntxiv thiab siv, uas yog qhov tseem ceeb rau lub hlwb txoj haujlwm. Thiab nws tuaj yeem pom txawm tias koj noj cov piam thaj ntau npaum li cas los ntawm koj cov zaub mov. Lub tshuab tawg. Nws zoo li muaj lub tsheb uas yuav tsis pib. Nws tsis muaj teeb meem npaum li cas roj av koj tso rau hauv nws, lub cav yuav tsis tig mus thiab tsim lub zog. Lossis yog tias koj muaj hmoo thiab nws ua tau, nws yuav tsis ua haujlwm tsis tu ncua. Ntxiv dua thiab, nws tsis muaj teeb meem ntau npaum li cas roj (qabzib) nyob hauv lub tank. Lub tshuab (lub cav) malfunctioning.
Kev nkag siab thiab txheeb xyuas lub hlwb hypometabolism tau ua kom pom tseeb ntawm ntau yam kab mob neurodegenerative. Thiab nws tsuas yog tsis tau txais kev saib xyuas txaus raws li tus neeg tsav tsheb ntawm pathology hauv kev puas siab puas ntsws. Tab sis peb tsis muaj kev saib xyuas rau nws hauv cov neeg uas muaj kev mob hlwb yeej tsis tau txhais hais tias nws tsis tseem ceeb lossis tsis muaj nyob.
Yog li, koj yuav tsis xav tsis thoob thaum kuv qhia koj tias cov kws tshawb fawb pom cov cheeb tsam ntawm hypometabolism hauv cov neeg uas muaj Binge Eating Disorder (BED).
Hypoactivity nyob rau hauv lub frontostriatal circuits tau tshaj tawm nyob rau hauv plaub qhov kev tshawb fawb fMRI ntawm BN cov neeg mob hauv lub xeev mob hnyav.
Donnelly, B., Touyz, S., Hay, P., Burton, A., Russell, J., & Caterson, I. (2018). Neuroimaging nyob rau hauv bulimia nervosa thiab binge noj tsis meej: ib tug systematic tshuaj xyuas. Phau ntawv Journal of Eating Disorders, 6(1), 1-24. https://doi.org/10.1186/s40337-018-0187-1
Tam sim no, kuv xav qhia rau koj, rau qhov pom tseeb, tias feem ntau ntawm cov kev tshawb fawb neuroimaging saib ntawm thaj chaw ntawm kev txo qis lossis hypometabolism yog saib ntawm Bulimia Nervosa (BN) thiab tsis yog Binge Eating Disorders (BED) tshwj xeeb. Hauv kev tshuaj xyuas tsis ntev los no ntawm kev tshawb fawb neuroimaging, lawv pom tias tsuas yog peb ntawm peb caug-ob qhov kev tshawb fawb uas lawv tau tshuaj xyuas piv rau BN thiab BED pawg.
Thiab thaum kuv paub kuv hais tias kuv yuav tsis mus rau hauv cov txheej txheem kuaj mob ntawm Binge Eating Disorder (BED), Kuv tsis xav kom koj tau txais qhov kev xav tias vim tias txoj haujlwm feem ntau ua tiav nrog cov neeg mob Bulimia, tias nws tsis cuam tshuam li cas. Siv sijhawm ib pliag los saib qhov sib txawv ntawm qhov sib txawv ntawm ob, raws li tau teev tseg hauv Diagnostic and Statistical Manual (DSM-V).
| Txheem | Bulimia Nervosa: Cov tsos mob (BN) | Binge Eating Disorder (BED) |
| Binge Eating Episodes | tam sim no | tam sim no |
| Compensatory Cwj Pwm | Tam sim no (piv txwv li, ntuav tus kheej, kev siv cov tshuaj laxative tsis raug) | Tsis muaj tam sim no |
| Ntau zaus ntawm kev coj cwj pwm | Tsawg kawg ib zaug ib lub lim tiam rau peb lub hlis | Tsawg kawg ib zaug ib lub lim tiam rau peb lub hlis |
| Kev Ntsuas Tus Kheej | Unduly cuam tshuam los ntawm lub cev zoo thiab qhov hnyav | Tsis yog ib qho kev kuaj mob tshwj xeeb |
| Kev ntxhov siab | Cim kev nyuaj siab txog kev noj binge | Feem ntau hais txog binge noj nws tus kheej |
| Ua kom pom tseeb ntawm Kev Ntsuas | Binge noj mov ua raws li kev coj tus cwj pwm | Binge noj yam tsis tau them tus cwj pwm |
| Psychological Impact | Feem ntau muaj feem xyuam rau ob qho tib si binge noj thiab kev coj cwj pwm | Feem ntau hais txog binge noj nws tus kheej |
Ib yam dab tsi yog tsav lub binge rau ob qho kev kuaj mob no.
Qee qhov kev tshawb fawb pom tau ua tiav thaum lub sijhawm ua haujlwm, saib seb thaj chaw ntawm lub hlwb tau qhib lossis tsis qhib lub sijhawm. Thaum lub sij hawm kev txawj ntse lossis kev ua haujlwm, thaj chaw hypometabolic yuav tsis pom qhov kev xav tau nce hauv kev ua haujlwm vim tias nws txo qis metabolic muaj peev xwm (muaj peev xwm ua kom muaj zog). Qhov tsis muaj lus teb lossis txo qis ua kom nquag plias tuaj yeem yog qhov tshwm sim ncaj qha ntawm cov hauv qab hypometabolism.
Tsis ntev los no, peb tau pom qhov sib txawv ntawm kev ua kom lub hlwb sib txawv ntawm cov neeg rog rog nrog thiab tsis muaj BED thaum lub sij hawm tswj kev paub, nrog rau pawg BED ua kom pom kev ua kom qis qis hauv IFG, vmPFC, thiab insula (38).
Donnelly, B., Touyz, S., Hay, P., Burton, A., Russell, J., & Caterson, I. (2018). Neuroimaging nyob rau hauv bulimia nervosa thiab binge noj tsis meej: ib tug systematic tshuaj xyuas. Phau ntawv Journal of Eating Disorders, 6(1), 1-24. https://doi.org/10.1186/s40337-018-0187-1
Neuroimaging cov kev tshawb fawb uas tau tsom mus rau Binge Eating Disorder (BED) qhia qhov sib txawv tseem ceeb hauv lub hlwb kev ua si, qhia tias cov neeg rog rog nrog BED pom tias txo qis kev ua si hauv Ventromedial Prefrontal Cortex (vmPFC) thaum raug zaub mov cues piv rau cov tsis muaj BED. Lub vmPFC yog qhov tseem ceeb rau kev txiav txim siab thiab cov lus teb rau lub siab xav, qhia tias BED cuam tshuam li cas tib neeg ua cov khoom noj uas muaj feem xyuam rau cov stimuli.
Kev tshawb fawb kuj tau pom tias thaum lub sij hawm kev txawj ntse tswj cov dej num, cov neeg rog rog nrog BED tau pom tias txo qis kev ua haujlwm hauv Inferior Frontal Gyrus (IFG) thiab Insula. Qhov kev poob qis no hauv IFG thiab Insula ntawm BED cov tib neeg yog qhov xav tau los taw qhia txog qhov sib txawv ntawm lawv lub peev xwm los siv kev paub txog kev tswj hwm thiab seb lawv pom cov xeev sab hauv cuam tshuam li cas rau kev noj mov.
Cov txheej txheem neural tshwj xeeb hauv BED qhia txo qis kev ua haujlwm, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam ntawm lub paj hlwb cuam tshuam nrog kev txiav txim siab, kev xav, thiab kev paub tswj hauv cov ntsiab lus ntawm kev noj mov.
Puas yog qhov kev cuam tshuam uas cuam tshuam txog qhov txo qis los ntawm hypometabolism hauv cov neeg no yuav yog ib qho kev kho mob tseem ceeb?
Kuv nyob ntawm no los qhia rau koj ib tug muaj.
Kev noj zaub mov ketogenic yog paub txog kev kho mob rau cov mob uas muaj thaj chaw ntawm lub hlwb hypometabolism. Lawv muab lwm cov roj ntxiv rau hauv daim ntawv ntawm ketones uas tau nkag los ntawm lub hlwb tshaib plab rau lub zog thiab hla cov khoom qab zib tawg uas koom nrog hauv cov xeev hypometabolic. Thiab peb tau paub qhov no tau ntev heev.
... lub hlwb muaj peev xwm thiab cia siab, tsawg kawg hauv ib feem, ntawm lwm cov substrates, tshwj xeeb tshaj yog lub cev ketone.
Sokoloff, LOUIS (1973). Metabolism ntawm ketone lub cev los ntawm lub hlwb. Kev tshuaj xyuas txhua xyoo ntawm cov tshuaj, 24(1), 271-280. https://doi.org/10.1146/annurev.me.24.020173.001415
Ib zaug hauv cov neuron, ketone lub cev tau dhau los ntawm kev hloov pauv biochemical uas ua rau lawv siv los ntawm cov saw hlau thauj hluav taws xob los tsim ATP (lub zog). Tsis tsuas yog lawv ua hauj lwm raws li ib tug roj qhov chaw, tab sis lawv kuj yog ib tug nyiam roj qhov chaw, muaj peev xwm ntawm yielding ntau ATP (lub zog) dua li pom nrog cov qabzib siv, ua kom nws zoo dua. Qhov no txhim kho ATP (lub zog) tsim los ntawm ketone metabolism tuaj yeem pab tiv thaiv hypometabolism los ntawm kev siv cov piam thaj tsis zoo.
Kuv tsis xav kom koj xav tias vim tias tsis muaj Randomized Controlled Trials (RCTs) tsis tau (thaum lub sijhawm ntawm tsab xov xwm no) siv cov khoom noj ketogenic tshwj xeeb rau Binge Eating Disorder (BED), peb tsis paub thiab nkag siab txog txoj hauv kev uas Kev noj zaub mov ketogenic muaj peev xwm kho cov kab mob hauv qab peb pom kev tsav tsheb lossis txhawb nqa cov tsos mob.
Ketone lub cev (KBs) yog qhov tseem ceeb ntawm lub zog rau lub hlwb.
Morris, AAM (2005). Cerebral ketone lub cev metabolism. Phau ntawv Journal of inherited metabolic disease, 28(2), 109-121. https://doi.org/10.1007/s10545-005-5518-0
Kuv xav taw qhia tias txhawm rau kom tswj tau tus kheej, koj yuav tsum muaj lub ntsej muag lub ntsej muag ua haujlwm txhawm rau tsav tus cwj pwm tsis zoo. Kuv nyuam qhuav qhia rau koj tias cov ntaub ntawv tshawb fawb muaj tshwm sim uas qhia tias cov neeg muaj kev ntxhov siab binge muaj thaj chaw hauv lawv lub ntsej muag lobe uas tsis ua kom txaus, feem ntau yog vim muaj cov txheej txheem hypometabolic.
Raws li peb txav mus rau qhov cuam tshuam ntawm cov khoom noj ketogenic ntawm cov tshuaj neurotransmitters thiab dhau ntawm qhov seem ntawm tsab xov xwm no, kuv xav kom koj khaws cia hauv siab.
Tab sis qhov ntawd tsuas yog ib txoj hauv kev noj zaub mov ketogenic tuaj yeem pab hloov qhov peb pom tshwm sim hauv lub hlwb ntawm cov tib neeg uas muaj Binge Eating Disorder (BED). Cia peb mus thiab saib lwm txoj hauv kev uas nws tuaj yeem ua kev kho mob.
Neurotransmitter Imbalances hauv BED
Muaj ntau qhov cuam tshuam hauv kev ua haujlwm neurotransmitter pom nyob rau hauv cov tib neeg ntsib cov txheej txheem rau Binge Eating Disorder thiab ntau ntau ntawm cov tshuaj puas siab puas ntsws siv rau hauv kev sim los hloov kho lawv kom txo cov tsos mob.
Tab sis dab tsi yog qee qhov sib txawv hauv kev ua haujlwm neurotransmitter peb pom hauv Binge Eating Disorder (BED) uas cuam tshuam rau cov teebmeem pom nrog cov khoom noj ketogenic? Thaum peb tham txog kev ua haujlwm neurotransmitter, peb feem ntau tham txog tsis txaus lossis ntau dhau, tab sis tiag tiag, cov khawv koob nyob ib puag ncig yuav ua li cas cov neurotransmitters ua haujlwm.
Glutamate / GABA muaj nuj nqi
Glutamate muaj nuj nqi tseem ceeb hauv Binge Eating Disorder (BED). Ntau npaum li ntawd cov kws tshawb fawb tau tshawb xyuas cov glutamate receptors sib txawv raws li cov tshuaj muaj peev xwm rau kev kho mob. Glutamate receptors ua lub luag haujlwm hauv kev ua li cas tib neeg tau txais txiaj ntsig zoo thiab tswj kev noj zaub mov. Nws tau xav tias cov tshuaj tsim los hloov cov receptors no tuaj yeem pab tswj kev noj ntau dhau thiab noj ntau dhau los ntawm kev hloov pauv lub hlwb cov lus teb rau cov khoom noj khoom haus.
... qhov kev hloov pauv tsis zoo ntawm mGluR5 kuj txo qis kev noj zaub mov zoo li kev noj zaub mov, feem ntau hom kev noj zaub mov tsis zoo. Ua ke peb cov txiaj ntsig tau taw qhia mGluR5 raws li lub hom phiaj muaj peev xwm kho kev rog rog nrog rau cov kab mob cuam tshuam.
Oliveira, TP, Gonçalves, BD, Oliveira, BS, De Oliveira, ACP, Reis, HJ, Ferreira, CN, … & Vieira, LB (2021). Kev hloov pauv tsis zoo ntawm cov metabotropic glutamate Receptor hom 5 raws li qhov muaj peev xwm kho tau zoo hauv kev rog thiab kev noj qab haus huv zoo li kev coj cwj pwm. Frontiers hauv Neuroscience, 15, 631311. https://doi.org/10.3389/fnins.2021.631311
Lwm qhov kev pom zoo yog tias feem ntau, tom qab kev txhim kho kev nyuaj siab tom qab (PTSD), ntau yam kev noj zaub mov tsis zoo, suav nrog kev noj zaub mov tsis zoo, tuaj yeem txhim kho. Qee qhov kev tshawb fawb tau tsom mus rau kev sib koom hloov pauv hauv glutamatergic neurotransmission pom nyob rau hauv cov xwm txheej no. Nws yog xav tias overstimulation ntawm glutamate ua rau excitotoxicity, uas ua rau ib tug overactive hypothalamic-pituitary-adrenal axis, thiab kev raug mob los yog kev ntxhov siab vim heev hloov nyob rau hauv glutamate ua hauj lwm yuav ua rau qhov pib ntawm PTSD thiab tom qab noj mov tsis zoo.
Modulating glutamatergic kev ua ub no tuaj yeem yog ib txoj hauv kev tseem ceeb hauv kev kho cov tib neeg nrog cov teeb meem no.
Kev tshuaj xyuas tam sim no qhia tias hloov pauv glutamate muaj nuj nqi los ntawm kev raug mob lossis kev ntxhov siab heev tuaj yeem pab txhawb PTSD thiab tom qab noj mov tsis zoo, thiab qhov kev hloov kho glutamatergic yuav yog qhov kev kho mob tseem ceeb…
Murray, SL, & Holton, KF (2021). Post-traumatic stress disorder tuaj yeem teeb tsa theem neurobiological rau kev noj zaub mov tsis zoo: Kev tsom mus rau glutamatergic tsis ua haujlwm. Xav, 167, 105599. https://doi.org/10.1016/j.appet.2021.105599
Thaum glutamate suav hais tias yog ib qho excitatory neurotransmitter, y-amino-butyric acid (GABA) yog inhibitory. Cov tshuaj uas modulate GABA yog siv rau kev qaug dab peg thiab kev kho mob ntawm cawv thiab tshuaj yeeb tshuaj. Tab sis cov tshuaj tib yam no tau siv los kho Binge Eating Disorder (BED).
Txhawm rau kom yooj yim thiab piav qhia nws feem ntau, tsis zoo li "tsawg" GABA, lossis GABA muaj nuj nqi los cuam tshuam cov teebmeem excitatory pom nrog cov glutamate ntau lawm tau hais. GABA tau pom los ua kom muaj kev cuam tshuam rau cov nqi zog thiab kev noj zaub mov uas cuam tshuam nrog kev noj zaub mov ntau. Yeej, ua kom nws siab.
Tseeb, qhov ua kom muaj VTA [ventral tegmental cheeb tsam] GABAergic neurons inhibits dopaminergic neurons thiab sai sai inhibits sucrose kua licking hauv cov zaub mov txwv.
Yang, B. (2021). Thaum twg yuav tsum tsis txhob noj: ib qho kev pabcuam nres ntawm kev noj zaub mov los ntawm cov nucleus accumbens. Phau ntawv Journal ntawm Neuroscience, 41(9), 1847-1849. https://doi.org/10.1523/JNEUROSCI.1666-20.2020
Dysfunction nyob rau hauv lub neurotransmitter GABA yog implicated muaj zog txaus cov tshuaj siv thaum nws los txog rau Binge Eating Disorder (BED), cov kws tshawb fawb pom GABA muaj nuj nqi cuam tshuam, txawm hais tias tsis muaj zog raws li pom nrog dopamine.
Tej zaum koj yuav xav tsis thoob thaum kawm tias cov tshuaj ADHD tau siv nrog cov pejxeem no, ib feem vim yog cov teebmeem ntawm cov tshuaj ntawm dopamine.
Cov tshuaj uas txhim kho noradrenergic thiab dopaminergic neurotransmission thiab / los yog muaj txiaj ntsig zoo hauv ADHD yog qhov chaw zoo tshaj plaws rau kev kho tshiab rau BED
Feng, B., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023). Kev Tshawb Fawb Tam sim no thiab yav tom ntej cuam tshuam txog kev noj zaub mov tsis zoo. International Journal of Environmental Research thiab Public Health, 20(14), 6325. https://doi.org/10.3390/ijerph20146325
Dopamine thiab Serotonin
Hauv cov xwm txheej uas tshwm sim los ntawm kev noj ntau dhau, raws li pom hauv Binge Eating Disorder (BED), muaj kev cuam tshuam hauv lub hlwb cov tes hauj lwm uas tseem ceeb rau kev txhawb siab, nrhiav kev txaus siab, kev txiav txim siab, thiab kev tswj tus kheej. Hauv txoj kev mesolimbic, qhov kev cuam tshuam no feem ntau cuam tshuam nrog glutamate thiab dopamine.
Thaum BED raug soj ntsuam nyob rau hauv lub teeb ntawm impulsive / compulsive noj zaub mov txoj kev xav, thiab nws cov kev tswj los ntawm lub paj hlwb khoom plig system hypotheses, dopaminergic neurotransmission zoo li qhov txaus nyiam tshaj plaws neuropathway tshawb.
Levitan, MN, Papelbaum, M., Carta, MG, Appolinario, JC, & Nardi, AE (2021). Kev noj zaub mov tsis zoo: Kev tshawb nrhiav 5-xyoo rov qab los ntawm kev sim tshuaj. Phau ntawv Journal of Experimental Pharmacology, 33-47. https://doi.org/10.2147/JEP.S255376
Kev noj zaub mov tsis zoo yog tus cwj pwm los ntawm lub xeev hyperdopaminergic, nrog rau kev ua kom muaj zog dopamine, lossis lub xeev hypodopaminergic, cim los ntawm kev txo qis dopamine.
D1 thiab D2 dopamine receptors, feem ntau nyob rau hauv lub striatum thiab prefrontal cortex, tswj cov haujlwm tseem ceeb xws li kev noj zaub mov, kev txiav txim siab, thiab kev ua haujlwm. Cov kev hloov hauv lawv qhov muaj thiab kev sib raug zoo cuam tshuam rau kev coj noj coj ua binge.
Genetic polymorphisms, tshwj xeeb tshaj yog nyob rau hauv D2, D3, thiab D4 receptor noob, pab txhawb rau tus kheej hloov pauv hauv kev ua haujlwm receptor. Cov kev sib txawv ntawm cov noob caj noob ces tuaj yeem cuam tshuam li cas ib tus neeg lub dopaminergic system teb rau ib puag ncig thiab kev coj cwj pwm, cuam tshuam rau lawv qhov cuam tshuam rau kev coj noj coj ua binge.
Tshaj li cov noob caj noob ces, dopamine receptor functionality yog hnyav heev los ntawm kev ua neej thiab ib puag ncig yam. Piv txwv li, ib txwm noj cov khoom noj muaj suab thaj lossis cov rog rog tuaj yeem hloov kho dopamine receptor muaj, zoo ib yam li cov kev hloov pauv neuroadaptive pom hauv kev siv yeeb tshuaj. Tsis tas li ntawd, lub paj hlwb cov neuroplasticity tso cai rau cov receptors no hloov mus rau hauv cov lus teb rau kev noj qab haus huv binge noj, muaj peev xwm txo qis cov lus teb dopamine dhau sijhawm.
Cov neurotransmitter dopamine koom nrog hauv kev xav noj zaub mov, kev txiav txim siab, kev ua haujlwm, thiab tus cwj pwm impulsivity; tag nrho cov no pab txhawb rau kev txhim kho thiab kev saib xyuas ntawm binge noj.
Blanco-Gandia, MC, Montagud-Romero, S., & Rodríguez-Arias, M. (2021). Binge noj mov thiab psychostimulant yees. World Journal of Psychiatry, 11(9), 517. http://dx.doi.org/10.5498/wjp.v11.i9.517
Kev ntxhov siab thiab lub siab lub ntsws kuj ua lub luag haujlwm tseem ceeb hauv kev hloov kho dopamine receptor muaj nuj nqi. Kev ntxhov siab ntev tuaj yeem hloov kho dopamine signaling txoj hauv kev, cuam tshuam rau receptor ntom thiab rhiab heev thiab yog li cuam tshuam rau cov qauv noj binge.
Pharmacological kev kho mob rau BED qee zaum muaj xws li xaiv serotonin reuptake inhibitors (SSRIs), uas ua rau kom lub sij hawm serotonin uas twb muaj lawm nyob rau hauv lub synapse ntawm neuron. Qhov no npaj siab ua kom muaj cov serotonin rau kev siv hauv lub hlwb. Hauv txoj kev loj hlob ntawm BED, muaj kev soj ntsuam tseem ceeb ntawm lub hlwb tsis zoo serotonin signaling, ib qho tseem ceeb hauv kev tswj kev xav thiab kev coj cwj pwm.
Nyob rau hauv txoj kev loj hlob ntawm BED nyob rau hauv tib neeg, impaired hlwb serotonin (5-HT) signaling tau raug pom.
Feng, B., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023). Kev Tshawb Fawb Tam sim no thiab yav tom ntej cuam tshuam txog kev noj zaub mov tsis zoo. International Journal of Environmental Research thiab Public Health, 20(14), 6325. https://doi.org/10.3390/ijerph20146325
Lub serotonergic system, koom nrog inducing satiety signals thiab mus ob peb vas kev cai, qhia tau hais tias tsis txaus nyob rau hauv BED, tshwj xeeb tshaj yog nyob rau hauv cov poj niam uas rog rog. Qhov no ua rau cov lus nug tsis txaus ntseeg: puas tuaj yeem noj ketogenic noj serotonin thiab lwm yam neurotransmitters hauv BED? Cov kev tshawb fawb tshwm sim taw qhia rau kev sib txuas zoo. Cov tshuaj siv rau kev kuaj mob no suav nrog Tricyclic Antidepressants (TCAs), Serotonin 5-HT2C Receptor Agonists, thiab Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs).
Yog li, puas yuav muaj kev noj haus ketogenic cuam tshuam rau cov no thiab lwm yam cuam tshuam rau cov neurotransmitters cuam tshuam rau kev kho Binge Eating Disorder (BED)?
Nws zoo nkaus li muaj zog heev.
Nws tau pom tias kev noj zaub mov ketogenic tuaj yeem ua rau muaj kev hloov pauv hauv qib ntawm monoamine neurotransmitters, xws li serotonin thiab dopamine. Los ntawm kev hloov pauv lawv cov qib, cov khoom noj ketogenic tuaj yeem cuam tshuam rau lub hlwb cov nqi zog, uas yog feem ntau dysregulated hauv kev noj zaub mov tsis zoo. Qhov kev hloov pauv ntawm dopamine no tej zaum yuav yog ib qho ntawm cov txheej txheem los ntawm kev noj zaub mov ketogenic tuaj yeem pab ua kom cov lus teb rau cov zaub mov zoo thiab txo tus cwj pwm noj mov.
Thiab ketogenic noj zaub mov txawv txawv hauv lawv lub peev xwm los hloov dopamine thiab serotonin tsis cuam tshuam qhov sib npaug ntawm cov neurotransmitters. Qhov kev sib npaug no yog qhov tseem ceeb rau kev tswj hwm lub hlwb kom noj qab haus huv thiab tuaj yeem yog qhov tseem ceeb hauv kev noj haus cov txheej txheem ntawm kev ua haujlwm raws li kev kho mob rau qhov no thiab lwm yam kev puas siab puas ntsws. Tam sim no peb tsis muaj cov tshuaj uas muaj peev xwm tswj tau qhov sib npaug ntawm ntau lub tshuab neurotransmitter tsis tu ncua lossis ua tau zoo yam tsis muaj qhov cuam tshuam loj heev uas tuaj yeem ua rau lub neej zoo rau cov neeg mob. Thiab tseem, kev noj zaub mov ketogenic tau qhia pov thawj tias nws tuaj yeem ua tiav qhov haujlwm no yam tsis muaj qhov tsis sib xws lossis cov kev mob tshwm sim tam sim no cov neeg mob yuav tsum tau nyiaj dhau.
Lwm txoj kev kho mob suav nrog β-Hydroxybutyrate (BHB), lub cev ketone tsim thaum lub sijhawm ketosis. BHB tau raug qhia kom hloov kho dopaminergic neurons los ntawm inhibiting microglial activation uas tuaj yeem tsav neuroinflamation. Los ntawm kev txo qis microglial activation, BHB tuaj yeem tiv thaiv dopaminergic neurons, muaj feem cuam tshuam rau qib dopamine thiab teeb liab hauv lub hlwb.
Kev hloov pauv ntawm dopamine pom hauv kev noj zaub mov ketogenic tuaj yeem ua rau muaj kev hloov pauv hauv lub hlwb cov nqi zog thiab tag nrho cov neurotransmitter tshuav nyiaj li cas, muab txoj hauv kev kho mob rau kev tswj cov teeb meem cuam tshuam nrog dopamine dysregulation.
Raws li cov ntaub ntawv pov thawj no, ketone lub cev tuaj yeem tswj hwm qhov tso tawm ntawm cov neurotransmitters xws li GABA, glutamate, serotonin, dopamine, thiab lub hlwb-derived neurotrophic yam koom nrog hauv cov kab mob neurologic.
Chung, JY, Kim, OY, Song, J. (2022). Lub luag haujlwm ntawm ketone lub cev hauv cov ntshav qab zib ua rau dementia: sirtuins, insulin tsis kam, synaptic plasticity, mitochondrial dysfunction, thiab neurotransmitter. Kev tshuaj xyuas zaub mov, 80(4), 774-785. https://doi.org/10.1093/nutrit/nuab118
Kev noj zaub mov ketogenic tau paub txog cov teebmeem ntawm neurotransmitter modulation uas yuav qhia nws muab kev kho mob rau cov neurotransmitters pom tias muaj feem cuam tshuam hauv kev tsim thiab kev saib xyuas ntawm kev noj zaub mov zoo.
Tab sis dab tsi txog lwm cov txheej txheem hauv qab peb pom muaj kev cuam tshuam hauv qhov teeb meem no? Puas yog neuroinflammation thiab oxidative kev nyuaj siab kuj pom nyob rau hauv qhov teeb meem no, raws li muaj ntau yam uas tau tshawb fawb thiab sau txog ntawm no blog?
Cov lus teb yog.
Neuroinflammation thiab Oxidative Stress hauv BED
Neuroinflamation tuaj yeem tshwm sim rau ntau yam laj thawj. Nws tuaj yeem yog vim cov neurons tawm tsam rau lub zog, micronutrient tsis txaus cuam tshuam nrog kev ua haujlwm ntawm lub paj hlwb thiab kev saib xyuas hauv tsev, lossis raug rau cov khoom uas tau hla cov ntshav-hlwb teeb meem uas yuav tsum tsis txhob muaj. Los yog, lub hlwb ntxuav hauv qabzib (qab zib) qib nws siv tsis tau vim yog lub hlwb tsis kam tiv thaiv insulin.
Nws kuj tshwm sim thaum lub cev tsis muaj zog ua haujlwm vim muaj tus kab mob lossis kab mob. Txawm hais tias yog vim li cas, lub hlwb lub cev tiv thaiv kab mob tau qhib thaum muaj kev ntxhov siab no. Thiab feem ntau, qhov ntawd yog qhov zoo. Nws tso tawm proinflammatory cytokines los pab ua kom cov khoom rov qab zoo li qub. Neuroinflamation yog ib qho lus teb neuroimmunological uas tiv thaiv koj. Tab sis nyob rau hauv ntau yam ntawm kev puas siab puas ntsws tej yam kev mob tau tham nyob rau hauv no blog, neuroinflammation ua ib tug mob ntev ntawm cov tsos mob.
Yog li ib zaug ntxiv, nws yuav tsum tuaj raws li tsis xav tsis thoob tias neuroinflamation tau raug txheeb xyuas tias yog ib qho kev cuam tshuam ntawm kev noj zaub mov tsis zoo, suav nrog Binge Eating Disorder (BED). Kev nce qib ntawm proinflammatory cytokines xws li Tumor Necrosis Factor Alpha (TNFα), Interleukin 1 Beta (IL1ß), thiab Interleukin 6 (IL6) yog cov cim qhia ntawm neuroinflammatory mechanisms. Cov cytokines no yog ib qho tseem ceeb rau cov txheej txheem inflammatory, thiab lawv qhov nce siab hauv kev noj zaub mov tsis zoo qhia tias lawv ua lub luag haujlwm ntawm neuroinflammation hauv pathology ntawm cov mob no.
Hais txog ED, nce ntshav plasma concentrations ntawm proinflammatory cytokines (TNFα, IL1ß thiab IL6) nrog rau lwm yam inflammatory thiab oxido-nitrosative mediators (COX2, TBARS) tau raug tshaj tawm.
Ruiz-Guerrero, F., Del Barrio, AG, de la Torre-Luque, A., Ayad-Ahmed, W., Beato-Fernandez, L., Montes, FP, … & Díaz-Marsá, M. (2023) . Oxidative stress thiab inflammatory pathways nyob rau hauv cov poj niam noj mov tsis zoo thiab ciam teb tus cwj pwm tsis zoo nrog lub siab lub ntsws dysregulation raws li kev sib txuas nrog impulsivity thiab raug mob. Psychoneuroendocrinology, 158, 106383. https://doi.org/10.1016/j.psyneuen.2023.106383
Rau cov tib neeg uas muaj BED thiab comorbid rog rog, qhov muaj nyob ntev, qis-qib o yog cov ntaub ntawv zoo, nrog rau cov kab mob hauv cov qauv tsiaj txuas nrog lub hlwb ua haujlwm uas cuam tshuam rau kev xav thiab kev nco.
Pro-inflammatory cytokines koom nrog kev tswj hwm kev noj zaub mov los ntawm kev ua haujlwm ntawm hypothalamus thiab xav tias yuav cuam tshuam qhov sib npaug ntawm orexigenic (qab los noj mov) thiab anorexigenic (qab los noj mov) cov neurons nyob rau hauv lub hypothalamus, muaj feem cuam tshuam rau qab los noj mov thiab satiety kev cai.
Cov pov thawj tam sim no qhia tau hais tias muaj peev xwm ua tau ob txoj kev sib raug zoo ntawm cov kab mob / cov kab mob tiv thaiv kab mob thiab kev noj qab haus huv ntsig txog kev noj zaub mov.
Meng, Y., & Kautz, A. (2022). Kev tshuaj xyuas pov thawj ntawm kev sib koom ua ke ntawm kev tiv thaiv kab mob thiab cov kab mob inflammatory nrog rau kev rog rog txog kev noj zaub mov. Frontiers hauv Immunology, 13, 902114. https://doi.org/10.3389/fimmu.2022.902114
Thaum neuroinflammation yog mob ntev, lub cev cov tshuaj tiv thaiv kab mob antioxidant uas siv los ntxuav cov kev puas tsuaj uas neuroinflammation tuaj yeem ua tsis txaus. Qhov no yog thaum oxidative kev nyuaj siab tshwm sim. Lo lus hais txog lub hlwb tsis muaj peev xwm ua kom tau raws li qib kev puas tsuaj uas tau ua.
Yog tias koj tseem me ntsis tsis meej txog qhov sib txawv ntawm neuroinflammation thiab oxidative kev nyuaj siab, koj tuaj yeem txaus siab rau cov lus hauv qab no.
Nrog rau lub zog ntawm kev tshawb fawb tau lees paub tias ob qho tib si neuroinflammation thiab oxidative kev ntxhov siab muaj nyob rau hauv cov neeg noj zaub mov tsis zoo, thiab hauv Binge Eating Disorder (BED) tshwj xeeb, nws ua rau cov lus nug ntawm seb cov khoom noj ketogenic tuaj yeem ua rau muaj txiaj ntsig zoo rau cov teeb meem no.
Cia kuv teb koj cov lus nug nrog lub suab nrov yog.
βOHB yog ib qho inhibitor ntawm histone deacetylases uas ua rau upregulation ntawm cov noob koom tes hauv kev tiv thaiv oxidative kev nyuaj siab ...
Achanta, LB, & Rae, CD (2017). β-Hydroxybutyrate nyob rau hauv lub hlwb: ib tug molecule, ntau yam mechanisms. Kev tshawb fawb Neurochemical, 42, 35-49. https://doi.org/10.1007/s11064-016-2099-2
Cov khoom lag luam fatty acid ntawm KD kuj tseem qhib cov ntsiab lus ntawm cov proteins uas txhawb kev tiv thaiv neuroprotection los ntawm kev tswj cov kev qhia ntawm pro-mitochondrial antioxidant thiab anti-inflammatory signals.
Kev noj zaub mov ketogenic cuam tshuam rau oxidative kev ntxhov siab hauv lub hlwb, ib feem los ntawm kev ua haujlwm ntawm NRF2 txoj hauv kev. NRF2 (Nuclear Factor Erythroid 2-Related Factor 2) yog qhov tseem ceeb ntawm kev hloov pauv uas tswj cov cellular teb rau oxidative kev nyuaj siab los ntawm kev pib cov ntaub ntawv ntawm ntau cov noob muaj lub luag haujlwm rau kev tiv thaiv antioxidant thiab detoxification.
Vim li cas nws tseem ceeb, thiab vim li cas peb yuav tsum saib xyuas qhov no rau lub hlwb noj qab haus huv thiab ua ib txoj hauv kev kho mob xws li Binge Eating Disorder (BED) thiab ntau lwm tus?
Vim tias nws ua rau muaj kev tsim cov tshuaj antioxidant tseem ceeb xws li glutathione, nrog rau lwm cov enzymes tseem ceeb koom nrog hauv neutralizing reactive oxygen thiab nitrogen hom. Cov kev hloov pauv molecular no ua rau muaj txiaj ntsig zoo rau kev txo qis oxidative kev ntxhov siab hauv lub hlwb. Txhim kho los ntawm kev noj zaub mov ketogenic, qhov NRF2-mediated antioxidant teb yog qhov hloov pauv kev ua si vim nws pab tiv thaiv cov hlwb neural los ntawm kev puas tsuaj oxidative.
Kev noj zaub mov ketogenic kuj hloov pauv PPARgamma (Peroxisome Proliferator-Activated Receptor Gamma). PPARgamma yog ib qho tseem ceeb ntawm cov receptors uas ua lub luag haujlwm tseem ceeb hauv kev tswj cov lipid metabolism, qabzib homeostasis, thiab lub zog sib npaug. Ntau tshaj li kev tswj hwm kev ua haujlwm hauv metabolic, PPARgamma yog qhov tseem ceeb hauv kev tswj hwm ntau yam ntawm cov noob uas cuam tshuam nrog cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv antioxidant. Thaum ua haujlwm nws ua rau kev hloov pauv ntawm cov noob uas txhim kho cellular metabolism, txo qhov mob, thiab txhim kho mitochondrial muaj nuj nqi. Qhov no yog ib qho tseem ceeb mechanism ntawm kev txiav txim muab cov kev pab kho mob.
Xaus: Sib koom ua pov thawj-raws li lwm txoj kev
Binge Eating Disorder (BED) yog qhov kev sib tw loj heev, cuam tshuam txog li 0.9% ntawm cov neeg hauv lawv lub neej. Nws yog qhov kev noj zaub mov ntau tshaj plaws, feem ntau nrog rau kev puas siab puas ntsws thiab cov teeb meem kev rog rog.
Cov tswv yim tam sim no tsis muaj txiaj ntsig txaus rau txhua tus. Thiab tseem, cov zaub mov ketogenic ncaj qha hais txog cov neurobiological thiab metabolic tsis txaus uas tuaj yeem pab tsav Binge Eating Disorder (BED). Hypometabolism, neurotransmitter imbalances, neuroinflammation, oxidative kev nyuaj siab - cov khoom noj ketogenic tau pom muaj peev xwm tswj tau cov no, thiab ntau ntxiv.
Raws li cov pov thawj scientific uas tau nthuav tawm yog li ntawd ... Qhov kev sib koom ua ke no yuav tsum sib koom ua ke txoj kev npaj kho mob hauv lub neej nrog kev npaj zaub mov noj qab haus huv, PA, thiab kev coj tus cwj pwm, raws li pab pawg kws tshaj lij
Feng, B., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023). Kev Tshawb Fawb Tam sim no thiab yav tom ntej cuam tshuam txog kev noj zaub mov tsis zoo. Phau Ntawv Xov Xwm Thoob Ntiaj Teb ntawm Kev Tshawb Nrhiav Ib puag ncig thiab Kev Noj Qab Haus Huv, 20(14), 6325. https://doi.org/10.3390/ijerph20146325
Thaum cov neeg tshawb fawb soj ntsuam cov neeg tawm tswv yim rau txoj kev npaj kho mob hauv lub neej uas suav nrog kev noj zaub mov, kev ua si lub cev, thiab kev coj cwj pwm, nws pom tseeb tias qhov twg cov khoom noj ketogenic haum. Nws tsis yog lwm txoj hauv kev tab sis yog ib qho kev xaiv tsim nyog, txhawb nqa los ntawm cov pov thawj tshawb fawb, kom muab tso rau hauv tus qauv kev saib xyuas rau BED.
Muab qhov muaj ntau ntawm BED thiab qhov tseeb tias kev kho mob tam sim no tsis ua haujlwm rau txhua tus, ketogenic noj zaub mov muaj kev cia siab. Nws yog ib txoj hauv kev ncaj qha, pov thawj-raws li txoj hauv kev uas tuaj yeem ua qhov sib txawv tiag tiag rau ntau tus. Cov kws saib xyuas kev noj qab haus huv thiab kev puas siab puas ntsws yuav tsum xav txog nws yog ib feem ntawm txoj kev kho mob ntau yam rau BED.
Kuv cov lus nug yuav yog, yog tias cov lus pom zoo kho mob tau muab tso rau hauv cov ntaub ntawv, vim li cas thiaj tsis suav nrog ketogenic noj? Yog tias koj lossis ib tus neeg koj hlub raug kev txom nyem los ntawm Binge Eating Disorder (BED), Kuv xav tias koj tuaj yeem ua ib rooj plaub rau qhov ntawd nrog koj cov kev paub tshiab los ntawm kab lus no. Koj tus kws kho mob tuaj yeem xa mus rau tus kws kho mob lossis tus kws kho mob noj zaub mov, thiab koj tuaj yeem thov kom lawv tau txais kev cob qhia hauv cov zaub mov ketogenic thiab coj kom zoo dua ntawm kev cob qhia hauv lwm yam kev ua neej uas pom tau tias yuav pab tau zoo.
Thiab tam sim no koj nkag siab tias kev noj zaub mov ketogenic cuam tshuam li cas rau qee yam ntawm cov txheej txheem lom neeg uas ua rau muaj kev tsis sib haum xeeb, koj tuaj yeem nyob hauv qhov chaw zoo dua los ua qhov kev txiav txim siab tseem ceeb ntawm koj tus kheej. Nws yog kuv txoj kev cia siab tias koj nyob hauv txoj haujlwm zoo dua rau tus kheej tawm tswv yim nrog koj tus kws kho mob thiab lub tuam txhab pov hwm kom tau txais kev nkag mus rau ketogenic noj raws li kev kho mob dua li koj tau pib thaum koj pib.
Yog tias koj tab tom nrhiav ntxiv tus kws kho mob paub txog ketogenic rau koj pab neeg kho mob lossis pab pawg rau ib tus neeg koj hlub, kuv yuav pib ntawm Mental Health Keto Training and Resource Page.
Kev tshawb fawb ntawm cov txheej txheem hauv qab yog muaj zog. Tab sis kuv tsis xav kom koj xav tias tsab xov xwm no tsuas yog theoretical xwb. Kev tshawb fawb cov ntaub ntawv muaj tiag tiag siv cov khoom noj ketogenic raws li kev kho mob Binge Eating Disorder (BED). Thiab nws yog kuv zoo siab los qhia koj txog qhov lawv pom hauv kab lus hauv qab no.
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Kuv tuaj yeem lees paub rau kuv tus kheej tias keto ua haujlwm tiag tiag los khaws kuv lub BED hauv daim tshev! Cia li sib ntaus sib tua! Muaj ntau ntau ntawm peb uas tau pab thiab txhawb nqa los ntawm koj qhov kev siv zog. Kuv muaj 54 xyoos thiab kuv tau muaj qhov teeb meem no txij li qib kawm ntawv. Yog kuv tsis binging, kuv tau zais zaub mov. Nws yog ib qho teeb meem loj uas tsis muaj cov kev daws teeb meem ntev ntev.