Cov tshuaj exogenous BHB puas tuaj yeem kho kuv tus mob puas hlwb?
kuv tau. Koj tsis xav hloov koj cov zaub mov. Nkag siab tag nrho. Thiab kuv teb rau seb exogenous β-Hydroxybutyrate (tseem hu ua beta hydroxy-butyrate lossis BHB) cov tshuaj yuav kho koj tus mob puas hlwb yog qhov kuv tsis paub. Thiab txawm tias cov kws tshaj lij ntawm exogenous ketones tsis paub. Txawm hais tias lawv xav hais tias yuav muaj txiaj ntsig zoo,
… Nws muaj peev xwm hais tias exogenous ketone supplementation-induced ketosis tej zaum yuav yog ib qho cuab yeej kho mob zoo tiv thaiv kab mob puas hlwb. Qhov tseeb, cov tshuaj exogenous ketone muaj kev cuam tshuam rau tus cwj pwm thiab cov nyhuv anxiolytic hauv kev tshawb fawb tsiaj.
Kovács, Z., D'Agostino, DP, Pob Zeb Diamond, D., Kindy, MS, Rogers, C., & Ari, C. (2019). Kev kho muaj peev xwm ntawm exogenous ketone ntxiv induced ketosis hauv kev kho mob ntawm kev puas siab puas ntsws: tshuaj xyuas cov ntaub ntawv tam sim no. Tus ciam nyob hauv hlwb, 363. https://doi.org/10.3389/fpsyt.2019.00363
Tam sim no Lub Xeev ntawm Kev Tshawb Fawb ntawm BHB Ntxiv
Tab sis thaum qhov kev tshuaj xyuas no tau sau rau xyoo 2019, kev tshawb fawb tsis tau ua tiav los teb cov lus nug ntawm seb BHB supplementation puas tuaj yeem kho mob hlwb. Thiab thaum lub sijhawm kuv sau ntawv blog no koj tab tom nyeem, peb tseem tsis paub cov lus teb. Kev tshawb fawb tseem tsis tau ua tiav txaus los teb cov lus nug ntawm seb BHB supplementation ib leeg puas yuav kho koj tus mob puas hlwb.
Tam sim no, tsis muaj kev tshawb fawb txog BHB ntxiv raws li kev kho mob ib leeg rau kev puas siab puas ntsws. Tam sim no, luam tawm cov ntaub ntawv tshawb fawb, kev sim sim, thiab Randomized Controlled Trials (RCTs) feem ntau yog tsom rau qhov ua tau zoo ntawm cov khoom noj ketogenic hauv kev kho mob hlwb. Kuv xav tias yav tom ntej, kev tshawb fawb yuav nthuav dav los tshawb xyuas BHB ntxiv rau cov kev mob hlwb sib txawv tshwj xeeb. Kuv yuav cia siab tias (thiab vam) yuav pom cov kev tshawb fawb sib piv cov txiaj ntsig ntawm cov neeg mob ntawm kev noj zaub mov ketogenic rau cov uas siv cov tshuaj BHB nkaus xwb. Tsis tas li ntawd, kev tshawb fawb tuaj yeem tshawb xyuas qhov sib xyaw ua ke ntawm cov khoom noj ketogenic thiab ntxiv ketone ntsev lossis lwm hom BHB.
Kev Noj Qab Haus Huv Ketogenic thiab Lawv Kev Sib Raug Zoo rau BHB
Cia peb saib qhov kev tshawb fawb zoo nkauj uas tau ua tiav tsis ntev dhau los, saib ntawm Kev kho muaj peev xwm ntawm Exogenous Ketone Supplement Induced Ketosis hauv Kev Kho Mob Psychiatric Disorders. Lawv tau txais txiaj ntsig zoo los ntawm kev tshawb fawb txog kev noj zaub mov ketogenic. Vim li cas? Vim tias cov khoom noj ketogenic tsim peb lub cev ketone, ib qho yog BHB.
Tab sis tsis muaj qhov twg hauv lawv qhov kev tshuaj xyuas lawv pom zoo kom koj sim siv exogenous BHB supplementation raws li kev kho mob rau koj lub hlwb. Lawv sib tham txog cov txheej txheem hauv qab uas BHB, ua lub cev ketone, pab kho cov kab mob hauv lub paj hlwb thiab kev puas siab puas ntsws, uas yog qhov zoo tshaj plaws thiab muaj kev cia siab. Cov kws sau ntawv yog cov kws tshawb fawb txog ketone lub cev thiab muaj kev paub txog kev kho mob uas siv cov ketones exogenous nrog ntau yam mob paj hlwb. Thiab txawm tias cov kws sau ntawv no hu rau cov kev tshawb fawb ntxiv mus saib rau kev siv exogenous BHB supplementation hauv cov neeg mob hlwb.
Vim li cas? Vim tias qhov kev tshawb fawb tam sim no zoo tshaj plaws txhawb kev siv cov khoom noj ketogenic rau cov kab mob neurological thiab ntau yam mob hlwb. Yam tsawg kawg ntawm lub sijhawm no.
Vim li cas Kev Tshawb Fawb Ntxiv yog qhov tseem ceeb
Tab sis qhov ntawd tsis yog qhov kawg ntawm peb qhov kev sib tham. Ua ib tus neeg xav paub kuv tus kheej, Kuv thov qhuas koj cov lus nug zoo thiab tsim nyog. Nws yog ib lo lus nug zoo tiag tiag. Thiab kuv xav kom koj paub tias tej yam no kuj tau xav txog los ntawm cov kws tshawb fawb.
Piv txwv li, muaj qee qhov kev tshawb fawb zoo siab cog lus thiab kev siv tshuaj kho mob rau BHB infusions raws li kev kho mob hauv cov xwm txheej mob hnyav.
Raws li BHB tuaj yeem ua haujlwm raws li lwm txoj hauv kev metabolic substrate rau qabzib thaum muaj kev ntxhov siab, muaj kev txaus siab rau kev siv IV BHB hauv kev mob hnyav, mob hauv cov neeg mob xws li mob hlwb raug mob, lossis ischemic raug mob rau lub hlwb lossis lub plawv.
Storoschuk, KL, Wood, TR, & Stubbs, BJ (2023). Kev tshuaj xyuas thiab meta-regression ntawm exogenous ketone infusion tus nqi thiab ua rau ketosis - Ib qho cuab yeej rau cov kws kho mob thiab cov kws tshawb fawb. Frontiers nyob rau hauv Physiology, 14. https://doi.org/10.3389/fphys.2023.1202186
Dab tsi yog tuav qhov no los ua ib qho kev xaiv hauv cov chaw kho mob tseem ceeb? Pom tau tias, tsis muaj BHB muag hauv daim ntawv no tseem muaj. Ib tug yuav tsum tau mus rau qhov ntawd!
... Lub luag haujlwm ntawm kev kho ketosis hauv cov mob hnyav xws li mob hlwb raug mob, mob stroke, plawv tsis ua hauj lwm thiab lwm yam kab mob tau raug tshawb xyuas tsawg dua vim tias tsis muaj cov khoom lag luam ntawm BHB intravenous.
White, H., Heffernan, AJ, Worrall, S., Grunsfeld, A., & Thomas, M. (2021). Kev Tshawb Fawb Txog Kev Kho Mob ntawm Intravenous β-Hydroxybutyrate Siv Hauv Tib Neeg-Kev Kho Mob Yav Tom Ntej?. Frontiers hauv Tshuaj, 1611. https://doi.org/10.3389/fmed.2021.740374
Yog tias muaj IV BHB yooj yim dua, kuv xav tias nws tseem yuav ntev ua ntej peb pom nws yog ib feem ntawm kev kho mob hlwb. Txawm hais tias kuv lees tias nws yuav txaus siab heev kom pom cov kev tshawb fawb tshawb fawb ua tib zoo tsim los siv rau hauv cov xwm txheej puas siab puas ntsws uas tseem tuaj yeem muab kev pom zoo, thiab IRB kev pom zoo ntawm txoj kev tshawb no yog ib qho kev xaiv.
Tab sis tsis tas yuav tos rau IV txoj kev xa khoom! Koj yuav tsum paub tias exogenous BHB supplementation tuaj yeem ua tau txhua yam ntawm cov ntaub ntawv tab sis feem ntau yog ua los ntawm kev sib xyaw ntawm BHB thiab ntxhia ntsev (piv txwv li, potassium, calcium, sodium, lossis magnesium). Kev sib xyaw ua ke (racemic) ntawm D thiab L-BHB cov ntawv, D-BHB ib leeg, thiab qee qhov uas tsis raug khi rau cov zaub mov (ntsev) muaj.
Muaj cov ketone esters uas muaj lawv tus kheej cov yam ntxwv thiab kev xav. Qee qhov muaj ob hom D thiab L ntawm BHB, qee qhov yog monoesters thiab muab D-BHB nkaus xwb. Muaj cov kev xav tau zoo xws li tus nqi thiab qee cov ntawv tasting zoo nkauj phem, tab sis kuj hais txog lawv cov teebmeem ntawm cov metabolism. Txhua yam yog qhov tseem ceeb uas yuav tsum tau soj ntsuam nrog cov neeg mob hlwb tab tom nrhiav siv lawv los ua ib qho ntxiv rau kev noj haus ketogenic lossis ua ib leeg kho mob rau cov tsos mob ntawm lub hlwb. Tag nrho cov kev hloov pauv no yuav tau txais txiaj ntsig los ntawm kev kawm.
BHB Supplementation Ib leeg: Kev Pom Kev Kho Mob
Kuv nyob qhov twg ntawm BHB supplementation ib leeg?
Kuv mus txuas ntxiv zoo siab heev txog kev tshawb fawb tshiab ntawm Beta-Hydroxybutyrate (BHB) thiab nws lub luag haujlwm hauv kev noj qab haus huv neuropsychiatric. Nws yog super cog lus. Txawm li cas los xij kuv xav kom meej meej nrog kuv lub tswv yim tam sim no ntawm kev siv BHB ua ib leeg kho mob rau kev puas siab puas ntsws thiab mob hlwb. Raws li kev tshawb fawb tawm, kuv lub tswv yim yuav hloov tag nrho. Raws li ib txwm muaj, kuv muaj cai hloov kuv lub tswv yim raws li qhov kuv kawm yav tom ntej thiab cov kev tshawb fawb zoo uas yuav tshwm sim tsis tau.
Tab sis ntawm no yog qhov khoom. Kuv tsis ntseeg tias tsuas yog ntxiv nrog BHB lossis ketone ntsev yuav pab tau zoo rau kev mob hlwb. Hauv kuv qhov kev kho mob, qee zaum kuv pom kev txhim kho hauv lub siab thiab kev txawj ntse siv Ketone Salts (BHB Salts) raws li ib qho ntxiv rau sab saum toj ntawm kev noj zaub mov zoo ketogenic uas yog optimized rau kev kho mob hlwb thiab neurological muaj nuj nqi. Kuv tau muaj ntau tus neeg sim tsuas yog ntxiv cov ntsev BHB ib leeg xwb, tsis hloov lawv cov zaub mov.
Txawm hais tias muaj qee tus neeg uas pom tias muaj kev txhim kho txaus thiab nres qhov ntawd, kuv yeej tsis tau pom qhov no ua rau muaj kev puas siab puas ntsws loj, xws li schizophrenia, bipolar, kev kho mob-kev nyuaj siab, lossis kev ntxhov siab ntev. Rau feem ntau, txhua qhov kev txhim kho pom hauv kev txo cov tsos mob tau piav qhia tias tsis txaus lossis sai sai. Cia peb tham txog vim li cas qhov ntawd yuav yog.
Cov kab mob puas siab puas ntsws yog cov xwm txheej nyuaj uas cuam tshuam los ntawm ntau yam, suav nrog cov noob caj noob ces, ib puag ncig, kev ua neej, thiab kev siv hlwb, txhua yam cuam tshuam loj heev los ntawm kev noj qab haus huv metabolic. Cov txiaj ntsig ntawm BHB hauv cov ntsiab lus ntawm kev noj zaub mov ketogenic yog ib feem ntawm kev hloov pauv hauv cov metabolism hauv lub cev thiab lub hlwb, kev hloov pauv uas tsis tau ua tiav los ntawm kev ntxiv tam sim no nrog BHB ib leeg.
Cov kev sib tw thiab qhov tseeb ntawm BHB Supplementation
Thaum BHB tuaj yeem muab lwm lub zog rau lub hlwb, nws tsis kho qhov teeb meem tseem ceeb ntawm kev tsis txaus siab ntawm cov piam thaj vim yog insulin tsis kam. Koj puas paub qhov koob tshuaj BHB koj yuav tsum tau noj kom thiaj li ua kom lub cev muaj zog zoo li lub hlwb? Los yog kho qhov tsis muaj zog tiv thaiv kab mob ua rau muaj mob neuroinflamation? Ntau npaum li cas BHB supplementation yog xav tau, thiab ntau npaum li cas nws yuav upregulate endogenous glutathione nyob rau hauv lub hlwb? Koj puas paub tias yuav tsum tau koob tshuaj npaum li cas txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau oxidative Koj puas paub cov koob tshuaj thiab lub sijhawm xav tau los kho lub hlwb txawm tias tus neeg tsis tau hloov pauv txoj kev ua neej xav tau los txo cov xwm txheej no ua rau muaj kev puas siab puas ntsws?
Koj tsis paub?
kuv thiab. Thiab tsis yog cov kws tshawb fawb.
Tab sis dhau ntawm qhov tsis paub txog qhov zoo meej npaum li cas rau txhua lub hlwb, muaj cov kev xav tau tiag tiag txog kev cia siab rau BHB cov tshuaj ntxiv.
Yog tias koj siv BHB ntsev (tseem hu ua ketone ntsev), koj yuav dhau qhov khoom noj khoom haus ntev ua ntej koj tau txais lub zog ruaj khov los txhawb koj lub hlwb.
Tab sis cia peb hais tias koj pom D-BHB ntxiv uas tsis txuas rau cov ntsev (minerals), vim tias lawv muaj nyob hauv khw. Tshaj li tus nqi ntau ntawm kev siv cov tshuaj no nyob rau ib hnub - tus nqi uas feem ntau txwv tsis pub rau ntau thiab tsis tau them los ntawm cov tuam txhab pov hwm tsis tau - muaj lwm qhov kev sib tw uas kuv xav paub tiag tiag txog.
Koj yuav ua li cas roj koj lub hlwb thaum koj pw? Thaum koj noj cov carbohydrates ntau dua tshwm sim thaum noj hmo vim tias koj tsis tau hloov koj cov zaub mov, thiab koj cov tshuaj insulin tsis kam tso cai rau tus nqi txaus lossis lub sijhawm ntawm ketone ntau lawm txhawm rau txhawm rau txhim kho neural networks, qhov ntawd txhais li cas rau lub hlwb sim kho? Kuv yuav qhia rau koj. Cov ntshav qab zib ntau ntxiv ua rau muaj kev cuam tshuam metabolic, uas BHB supplementation ib leeg tsis tuaj yeem kho tag nrho.
BHB muaj cov tshuaj tiv thaiv kab mob, tab sis cov ntshav qab zib ntev ntev thiab insulin tsis kam tuaj yeem ua rau muaj kab mob hauv lub hlwb. BHB tuaj yeem txo qee qhov mob, ua rau lub cev taw qhia lub cev tiv thaiv kab mob, tab sis nws tsis tso tseg cov lus teb tsis tu ncua uas tshwm sim los ntawm tus cwj pwm thiab ib puag ncig ua rau muaj kev pheej hmoo metabolic tsis txaus.
BHB tuaj yeem txo cov kev ntxhov siab oxidative, tab sis cov ntshav qab zib siab tsis tu ncua tsim cov pa oxygen reactive, tsim kom muaj kev puas tsuaj oxidative. BHB supplementation tuaj yeem pab, thiab yog, nws tuaj yeem ua raws li nws tus kheej daim ntawv ntawm antioxidant, tab sis nws tsis yog ib qho kev daws teeb meem rau oxidative kev nyuaj siab los ntawm kev mob hyperglycemia.
Kuv tuaj yeem mus hais txog yuav ua li cas tsis kho lub hlwb cov tshuaj insulin ua rau muaj kev hloov pauv ntawm cov neurotransmitter muaj nuj nqi, txo cov neuroplasticity, hormonal dysregulation, thiab cuam tshuam cov ntshav-hlwb teeb meem kev ncaj ncees, tab sis koj tau txais lub tswv yim.
Tsis tas li ntawd, cia li pov tawm qhov tseeb tias hloov koj cov zaub mov hloov koj lub plab microbiome los ntawm kev hloov cov roj muaj rau microbiota. Yog tias koj noj koj cov zaub mov ib txwm muaj, BHB ntxiv yuav tsis hloov qhov koj lub plab microbiome tau noj. Yog li ntawd, koj yuav tsis tau txais cov kev hloov pauv loj rau lub plab microbiome peb pom tias txhim kho kev qaug dab peg, uas yuav zoo heev yog ib feem ntawm cov txiaj ntsig kev kho mob uas peb pom hauv kev siv cov khoom noj ketogenic rau kev puas hlwb thiab kev puas hlwb.
Lub peev xwm kho tau ntawm BHB hauv kev puas siab puas ntsws metabolic yog, hauv kuv lub tswv yim tam sim no, feem ntau siv tau zoo nyob rau hauv lub moj khaum ntawm kev noj zaub mov zoo ketogenic. Qhov kev noj haus no ua rau muaj kev cuam tshuam ntawm lub xeev metabolic uas dhau mus dhau qhov cuam tshuam ntawm BHB supplementation, cuam tshuam ntau yam ntawm lub hlwb kev noj qab haus huv thiab kev ua haujlwm.
Thaum BHB qhia tau tias muaj peev xwm cuam tshuam qee yam ntawm lub hlwb ua haujlwm, kuv tsis xav tias nws yuav ua rau panacea. Kev tso siab nkaus xwb rau BHB cov tshuaj lossis cov ntsev ketone saib xyuas qhov tseem ceeb ntawm kev noj qab haus huv ntawm cov metabolism hauv kev puas siab puas ntsws, uas tej zaum yuav suav nrog kev noj zaub mov, kev kho mob hlwb, thiab kev ua neej hloov pauv uas txhim kho mitochondrial kev noj qab haus huv thiab kev ua haujlwm.
Xaus: Xav txog BHB Ntxiv thiab Kev Noj Qab Haus Huv
Cia peb sau qhov no nrog ib zaj dab neeg.
Ib zaug dhau los, muaj lub hlwb raug kev txom nyem los ntawm kev ua haujlwm loj hauv metabolic. Yog tias lub hlwb no yog ib lub tsev, nws yuav raug hluav taws kub hnyiab, lossis muaj ntau qhov chaw ntawm hluav taws. Thaum exogenous BHB supplementation yuav pab tua hluav taws, ib yam li cov thoob dej, peb tsis paub yuav ua li cas npaum li cas BHB yuav tsum tau ua kom tiav. Thiab yog tias tsis muaj kev noj zaub mov lossis kev coj tus cwj pwm hloov tau los txhim kho cov metabolism hauv lub hlwb, puas BHB supplementation tiag tiag yog kev kho mob? Los yog peb puas tsuas yog siv BHB supplementation ua lwm hom kev tswj cov tsos mob, txoj kev uas peb tam sim no sim ua nrog tshuaj?
Yog li ntxiv, kuv tau txais nws. Koj tsis xav hloov koj cov zaub mov.
Tab sis kuv paub rau qhov tseeb tias ntau tus ntawm koj yeej xav kho lub hauv paus ua rau koj mob hlwb thiab tau nrog koj lub neej, txaus siab rau koj qhov ua tau zoo tshaj plaws ntawm kev ua haujlwm. Kuv paub tias koj ib txhia yeej tshaib plab nrog cov tsos mob txo cov qauv. Lawv yeej tsis yog vim li cas koj tuaj nrhiav kev kho mob, thiab koj tau txais cov tshuaj tsuas yog txo cov tsos mob vim nws yog txhua yam lawv tau muab rau lub sijhawm.
Thiab kuv kuj paub tias qee tus ntawm koj zoo siab sim qee yam uas tsuas yog txo cov tsos mob. Thiab qhov ntawd yog txias, ib yam nkaus. Txhua tus muaj txoj cai paub txhua txoj hauv kev uas lawv tuaj yeem hnov zoo dua. Thiab BHB supplementation tuaj yeem ua qhov ntawd rau koj. BHB supplementation yuav cuam tshuam rau cov tshuaj, yog li nrhiav ib tus kws kho mob (cia siab tias ketogenic-kawm) los tham txog qhov zoo thiab qhov tsis zoo nrog koj hauv cov ntsiab lus ntawm koj cov tshuaj tam sim no thiab kev kuaj mob.
Txawm hais tias koj tab tom zaum nyob rau hauv lub camp twg, kuv vam tias tsab xov xwm no tau pab kom nkag siab txog lub luag haujlwm ntawm BHB supplementation hauv kev zoo siab.
References
Cornuti, S., Chen, S., Lupori, L., Finamore, F., Carli, F., Samad, M., Fenizia, S., Caldarelli, M., Damiani, F., Raimondi, F., Mazziotti, R., Magnan, C., Rocchiccioli, S., Gastaldelli, A., Baldi, P., & Tognini, P. (2023). Brain histone beta-hydroxybutyrylation ob leeg metabolism nrog cov noob qhia. Cellular thiab Molecular Lub Neej Kev Tshawb Fawb, 80(1), 28. https://doi.org/10.1007/s00018-022-04673-9
He, Y., Cheng, X., Zhou, T., Li, D., Peng, J., Xu, Y., & Huang, W. (2023). β-Hydroxybutyrate raws li ib qho kev hloov kho epigenetic: Cov txheej txheem hauv qab thiab cuam tshuam. hlo, 9(11). https://doi.org/10.1016/j.heliyon.2023.e21098
Kovács, Z., D'Agostino, DP, Pob Zeb Diamond, D., Kindy, MS, Rogers, C., & Ari, C. (2019). Kev Kho Mob Muaj Peev Xwm ntawm Exogenous Ketone Supplement Induced Ketosis hauv Kev Kho Mob Psychiatric Disorders: Kev Ntsuam Xyuas Cov Ntawv Sau Tam Sim No. Cov Hauv Paus Ntawm Kev Puas Siab Ntsws, 10. https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00363
Soto-Mota, A., Norwitz, NG, & Clarke, K. (2020). Vim li cas d-β-hydroxybutyrate monoester? Biochemical Society Transactions, 48(1), 51-59. https://doi.org/10.1042/BST20190240
Storoschuk, KL, Wood, TR, & Stubbs, BJ (2023). Kev tshuaj xyuas thiab meta-regression ntawm exogenous ketone infusion tus nqi thiab ua rau ketosis - Ib qho cuab yeej rau cov kws kho mob thiab cov kws tshawb fawb. Frontiers nyob rau hauv Physiology, 14, 1202186. https://doi.org/10.3389/fphys.2023.1202186
White, H., Heffernan, AJ, Worrall, S., Grunsfeld, A., & Thomas, M. (2021). Kev Tshawb Fawb Txog Kev Siv Tshuaj Txhaum β-Hydroxybutyrate hauv tib neeg - Kev Kho Mob Yav Tom Ntej? Frontiers hauv Tshuaj, 8. https://www.frontiersin.org/articles/10.3389/fmed.2021.740374
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