Mitochondria ua ntau dua li tsuas yog muab lub zog rau cov hlwb.
Kwv yees li ntawm lub sijhawm nyeem ntawv: 9 feeb
Tsis txhob ua rau kuv yuam kev. Lawv muaj txhua yam ua rau lub zog. Thiab vim tias lawv tseem ceeb heev rau kev tsim hluav taws xob, lawv ua lub luag haujlwm tseem ceeb hauv cov metabolism. Thiab yog li ntawd, lawv yog theem nruab nrab hauv thaj tsam ntawm Metabolic Psychiatry.
Peb hnov tias mitochondria yog lub zog ntawm lub xov tooj ntawm txhua qhov chaw. Los yog tsawg kawg kuv ua nyob rau hauv lub voj voog uas kuv dai rau hauv. Thiab koj yuav pom nws hais tag nrho los ntawm cov ntawv blog ntawm lub vev xaib no. Kev sib txuas lus tias mitochondria yog lub zog ntawm koj lub hlwb yog qhov yooj yim tshaj plaws thiab yooj yim tshaj plaws los hla rau koj uas koj xav tau lawv rau lub zog neuronal. Nws yooj yim to taub. Yog tias peb tsis muaj roj teeb ua haujlwm hauv lub teeb nyem, lub teeb nyem yuav tsis ua haujlwm. Thiab yog tias peb cov roj teeb tuag, nws yuav ua haujlwm zoo, tab sis tsis zoo heev. Thiab qhov ntawd mus rau peb lub hlwb thaum peb muaj mitochondrial dysfunction mus. Cells tsis tuaj yeem ua ntau txoj haujlwm uas lawv yuav tsum tau ua kom koj humming raws zoo.
Tab sis rau cov neeg ntawm koj uas xav paub ntau ntxiv, nws yog ib qho tseem ceeb kom paub tias mitochondria muaj ntau ntau dua li lub zog ntawm koj lub hlwb. Yog li hauv kev txaus siab ntawm kev nkag siab me ntsis ntxiv ntawm cov khoom siv yees duab me me no kuv tau sau cov ntawv blog no!
Lus Cim: Kuv tsis siv lo lus khawv koob maj mam. Yog tias koj tsis nyiam lo lus tej yam yees siv, los ntawm tag nrho cov txhais tau tias, hloov lo lus quantum. Yog vim li cas yog qhov tseeb thiab zoo nkauj darn txias. Tab sis dhau ntawm cov kab lus me me no (Kuv tsis yog tus kws kho mob).
Mitochondria txhais ntawm quantum thiab macroscopic worlds thiab Siv quantum tunneling ntawm electrons los txo cov kev ua kom muaj zog tiv thaiv rau electron flow. Electron tunneling tau nthuav dav hauv Complex I ntawm cov saw hlau thauj hluav taws xob.
Bennett, JP (2019). Kev kho mob hypothesis: Cov kab mob neurodegenerative tshwm sim los ntawm oxidative puas tsuaj rau electron tunneling proteins hauv mitochondria. Kev kho mob hypotheses, 127, 1-4.
Yog li cia peb nkag mus rau hauv lwm yam uas mitochondria ua lub luag haujlwm tseem ceeb hauv lwm yam tsis yog kev tsim hluav taws xob zoo xwb. Yog tias koj tau cia siab rau mitochondria tsab xov xwm tshwj xeeb rau ketogenic noj, koj muaj hmoo. Vim kuv sau ib. Koj tuaj yeem nrhiav nws ntawm no:
Kev ntxhov siab
Muaj kev ntxhov siab rau lub cev thiab kev ntxhov siab ntawm lub hlwb. Thiab koj lub cev lub peev xwm los daws cov kev ntxhov siab ntawm txhua yam los ntawm kev ua haujlwm mitochondrial. Koj puas tau kis tus kab mob lossis kab mob uas ua rau koj lub cev tsis muaj zog? Mitochondria tswj koj lub cev tiv thaiv kab mob ua haujlwm. Puas yog koj tab tom cuam tshuam nrog kev ntxhov siab ntawm kev puas siab puas ntsws uas nyuaj rau koj hauv koj lub neej? Mitochondria yog tus saib xyuas ntawm koj lub cell lub peev xwm hloov kho, muaj sia nyob thiab ua kom muaj zog dua los ntawm kev pib hloov pauv ntawm cov noob qhia thiab cov metabolism. Yog tias koj tsis muaj mitochondria noj qab nyob zoo thiab muaj ntau los txhawb cov hlwb ces ntau cov hlwb tuag, lossis phem dua. Lawv tig mus rau hauv cov zombies (senescence) uas tso tawm qee qhov kev mob tshwm sim tsis zoo uas ua rau koj cov kev ntxhov siab oxidative thiab ua rau koj cov tsos mob hnyav dua.
Kev tsim tshuaj hormones
Yog tias nws yog lub xov tooj ntawm tes uas ua rau cov tshuaj hormones, nws yog lub xov tooj ntawm tes uas xav tau lub zog ntau dua thiab qhov ntawd txhais tau hais tias koj lub mitochondria yog qhov tseem ceeb ntawm kev tsim cov tshuaj hormones. Yog lawm. Sterol cov tshuaj hormones xws li estrogen, testosterone, thiab cortisol. Mitochondria tuav tus yuam sij. Txoj cai los muab cov enzymes xav tau los pib tsim cov tshuaj hormones.
Qhov no yog vim li cas koj cov tshuaj kho mob rau adrenal qaug zog tsis ua haujlwm. Muab rau koj cog sterols los hloov koj tus kheej cortisol tsis hais txog kev ua haujlwm mitochondrial uas tab tom mus. Qhov no yog vim li cas mus rau kev kho tshuaj hormone hloov tsis yog qhov "hauv paus ua rau" cuam tshuam. Yog tias koj cov tshuaj hormones tawm ntawm whack, nws yog ib qho cim ntawm mitochondrial tsis ua haujlwm. Lub ntsiab lus ntawm kev cuam tshuam yog txhawm rau txhim kho koj txoj haujlwm mitochondrial.
Qhia rau koj cov phooj ywg.
Ntxuav cov messs
Yuav luag txhua tsab xov xwm hauv lub vev xaib no tham txog lub luag haujlwm ntawm oxidative kev nyuaj siab hauv kev puas siab puas ntsws thiab mob hlwb. Oxidative stress yog qhov peb hu ua lub nra ntawm kev sim kho qhov kev puas tsuaj uas tshwm sim vim Reactive Oxygen Species (ROS). Thaum koj cov mitochondria muaj ntau thiab noj qab haus huv koj feem ntau muaj tag nrho cov kev pab koj xav tau los kho cov theem ntawm kev puas tsuaj uas tshwm sim los ntawm kev ciaj sia thiab txav mus thoob ntiaj teb.
… mitochondria ua hauj lwm raws li ROS janitors.
(Palmer, 2022, nr 126)
Muaj ntau thiab ua haujlwm zoo mitochondria yuav tsum tau ua kom muaj kev ntxhov siab oxidative hauv kev kuaj xyuas. Thiab khaws oxidative kev ntxhov siab hauv kev kuaj xyuas yog xav tau kom muaj lub hlwb ua haujlwm. Oxidative kev ntxhov siab uas tsis khaws cia rau hauv daim tshev ua rau cov txheej txheem neurodegenerative uas cuam tshuam rau lub siab thiab kev txawj ntse ua haujlwm. Mitochondria yog qhov tseem ceeb hauv kev ua haujlwm thiab kev saib xyuas ntawm koj lub cev tus kheej hauv cov kab mob antioxidant. Thiab raws li kuv tau hais ntau zaus thoob plaws tag nrho cov ntawv blog, koj yuav tsis siv Vitamin C, turmeric, lossis curcumin koj txoj hauv kev tawm ntawm oxidative kev nyuaj siab los ntawm kev ua haujlwm tsis zoo lossis tsis txaus ntawm mitochondria.
Nug tus naj npawb ntawm cov neeg noj cov tshuaj tiv thaiv kab mob loj heev rau lawv cov kws kho mob cov lus pom zoo uas tseem muaj kev nyuaj siab kom zoo.
Qhia rau koj cov phooj ywg txog qhov ntawd thiab.
Yog tias koj tseem me ntsis tsis meej pem txog qhov sib txawv ntawm oxidative kev nyuaj siab thiab neuroinflamation thiab lawv cuam tshuam li cas, koj tuaj yeem tshawb xyuas cov lus hauv qab no:
Tab sis mitochondria yog ntau tshaj li cov neeg ua haujlwm tu thaum muaj kev puas tsuaj. Lawv pab tswj cov hlwb hauv txhua txoj hauv kev. Lawv tswj cov xov tooj ntawm tes tsim, pab tswj cov kev sib txuas tau raug tshem tawm thiab qhov twg nyob, thiab yog qhov tseem ceeb hauv cov txheej txheem rov ua dua tshiab uas yog ib feem ntawm kev noj qab haus huv ntawm tes (autophagy, cell apoptosis - hom cell tuag zoo). Nws tsis yog hais txog kev ntxuav cov messes tom qab lawv tau tshwm sim. Mitochondria tau ua kom muaj kev noj qab haus huv ntawm cov noob thiab kev ua haujlwm ntawm tes kom txo tau qhov kev pheej hmoo loj yuav tshwm sim thawj zaug.
Noob qhia
Cov kab hauv qab no yog koj cov noob yuav tsis qhia lawv tus kheej txoj cai yam tsis muaj kev noj qab haus huv mitochondria. Kwv yees li 20 xyoo dhau los lawv pom tias mitochondria xav tau los thauj cov protein uas pab tswj cov noob caj noob ces. Mitochondria muaj lawv tus kheej DNA thiab DNA codes rau cov proteins uas tswj cov noob caj noob ces. Thiab hais tias cov noob caj noob ces muaj kev cuam tshuam rau cov lus teb kev ntxhov siab, metabolism, thiab kev ua haujlwm antioxidant. Thaum cov kws tshawb fawb ua si nrog mitochondria los ntawm qhov tseem ceeb ua rau lawv tawg (txo lawv lub peev xwm ua haujlwm) lawv pom tias muaj teeb meem epigenetic ntau tshwm sim.
Qhov ntawd txhais li cas?
Nws txhais tau tias yog tias koj tsis xav kom koj cov noob qhia lawv tus kheej hauv kev lom zem uas ua rau muaj teeb meem thiab cov tsos mob thiab ua rau koj (thiab koj lub hlwb) muaj hnub nyoog sai dua, koj zoo dua tso koj txoj kev kawm kom muaj kev noj qab haus huv, thiab zoo siab mitochondria.
Yog tias koj vam tias yuav nkag siab me ntsis zoo dua li cas ketones cuam tshuam cov noob qhia, koj yuav nyiam cov kab lus no kuv tau sau ntawm no:
Neurotransmitter Synthesis
Mitochondria nyiam dai ntawm synapses. Yog tias koj cov mitochondria tsis tshua muaj pes tsawg los yog qee yam tau txais nyob rau hauv txoj kev ntawm lawv lub peev xwm mus rau qhov chaw lawv xav tau, ces koj tsis ua rau koj cov neurotransmitters. Thiab yog tias koj cov mitochondria tsis tshua muaj pes tsawg los yog tsis muaj txiaj ntsig lossis muaj mob ces cov neurotransmitters tuaj yeem ua tsis zoo.
Thiab qhov tsis txaus ntseeg neurotransmitters ua rau tsis yog rau cov teeb meem ntawm lub siab xwb tab sis kev paub txog teeb meem, ib yam nkaus. Koj xav tau kev noj qab haus huv thiab nplua nuj mitochondria los ua ke, tso tawm, thiab rov ua dua koj cov neurotransmitters thiab tom qab ntawd tsim cov enzymes uas ua rau lawv poob. Kuv paub peb txhua tus xav tias lub tswv yim yog kom koj cov neurotransmitters dai rau hauv cov synapses ntev dua, tab sis qhov ntawd tuaj yeem ua rau nws tus kheej teeb meem thaum lawv tsis tuaj yeem tawg.
Nws yog ib lub voj kev tawm tswv yim. Cov neurotransmitters tsim thiab siv ces muab mitochondria cov lus tseem ceeb uas siv los ua kom koj lub hlwb ua haujlwm zoo. Tsis muaj leej twg yog cov hauv paus rau koj lub hlwb ua haujlwm zoo li koj cov phooj ywg muaj zog, me me mitochondrial. Leej twg yog tus txhawb siab rau koj txoj kev xav ruaj khov? Leej twg xav kom koj xav tias ntse, tam sim no, thiab muaj peev xwm?
Nws yog koj mitochondria.
Rau cov kws kho mob puas siab puas ntsws siv cov tshuaj feem ntau los sim nce lossis txo qee yam neurotransmitters yam tsis xav txog kev noj qab haus huv mitochondrial, Kuv xav kom koj tshawb txog qee yam ntawm Metabolic Psychiatry kev cob qhia hauv nplooj ntawv hauv qab no.
xaus
Yog tias koj tsom mus rau tsis muaj lwm qhov ntawm kev txhim kho kev ua haujlwm hauv koj txoj kev rov zoo dua li kev ua haujlwm mitochondrial, koj yuav ua koj tus kheej qhov kev pabcuam zoo heev. Muaj ntau txoj hauv kev zoo los txhim kho mitochondrial muaj nuj nqi, thiab ib qho kev cuam tshuam muaj zog tshaj plaws rau kev nce mitochondrial tus lej thiab txhim kho mitochondrial muaj nuj nqi muaj cov khoom noj ketogenic.
Vim li cas? Vim tias cov khoom noj ketogenic nce tus naj npawb ntawm mitochondria thiab txhim kho kev noj qab haus huv thiab kev ua haujlwm ntawm mitochondria. Kev noj zaub mov ketogenic yog ib qho kev cuam tshuam mitochondrial uas cuam tshuam rau cov metabolism thiab tag nrho lwm cov dej num tseem ceeb uas tseem ceeb heev rau lub hlwb ua haujlwm uas tau teev tseg hauv tsab xov xwm no.
Hauv qab no yog qee cov ntawv uas tham txog vim li cas cov khoom noj ketogenic, thiab cov kev cai tom qab ntawm mitochondria uas tau tshwm sim, yog cov kev kho mob zoo rau ntau yam kev kuaj mob.
Yog tias koj tsis pom qhov kev kuaj mob uas koj xav nyeem txog, tsuas yog nqes mus rau qhov chaw tshawb nrhiav hauv qab ntawm nplooj ntawv!
Tam sim no koj muaj lub tswv yim zoo dua ntawm qee qhov kev ua haujlwm mitochondria muab, koj nyob hauv txoj haujlwm zoo dua kom txaus siab rau cov ntawv blog ntawm lub vev xaib no.
Yog tias koj xav tshawb nrhiav qhov program online hauv koj txoj kev taug kev los kawm txhua txoj hauv kev uas koj tuaj yeem hnov zoo dua, kuv xav kom koj kawm ntxiv txog kuv Txoj Haujlwm Pabcuam Hlwb Fog.
References
Anderson, AJ, Jackson, TD, Stroud, DA, & Stojanovski, D. (2019). Mitochondria-hubs rau kev tswj cov cellular biochemistry: cov ntsiab lus tawm thiab cov tes hauj lwm. Qhib biology, 9(8), 190126. https://doi.org/10.1098/rsob.190126
Bennett, JP (2019). Kev kho mob hypothesis: Cov kab mob neurodegenerative tshwm sim los ntawm oxidative puas tsuaj rau electron tunneling proteins hauv mitochondria. Kev kho mob Hypotheses, 127, 1-4. https://doi.org/10.1016/j.mehy.2019.03.034
Bennett, JP, & Onyango, IG (2021). Zog, Entropy thiab Quantum Tunneling ntawm Protons thiab Electrons nyob rau hauv Mitochondria Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Disease and Therapeutic Measures. bio tshuaj, 9(2), Tshooj 2. https://doi.org/10.3390/biomedicines9020225
Dzeja, PP, Bortolon, R., Perez-Terzic, C., Holmuhamedov, EL, & Terzic, A. (2002). Kev sib txuas lus nquag ntawm mitochondria thiab nucleus qhia los ntawm catalyzed phosphotransfer. Cov txheej txheem ntawm National Academy of Sciences, 99(15), 10156-10161. https://doi.org/10.1073/pnas.152259999
Kanellopoulos, AK, Mariano, V., Spinazzi, M., Woo, YJ, McLean, C., Pech, U., Li, KW, Armstrong, JD, Giangrande, A., Callaerts, P., Smit, AB, Abrahams, BS, Fiala, A., Achsel, T., & Bagni, C. (2020). Aralar Sequesters GABA rau hauv Hyperactive Mitochondria, Ua rau Social Beficits. cell, 180(6), 1178-1197.e20. https://doi.org/10.1016/j.cell.2020.02.044
Metabolic siab (Director). (2022, Kaum Ib Hlis 30). Mitochondria hauv hlwb thiab lub cev - Martin Picard PhD. https://www.youtube.com/watch?v=u51JSv4AK-0
Palmer, C. (2022). Lub hlwb zog (1st ed.). https://a.co/d/hKy6x2A
Picard, M., Zhang, J., Hancock, S., Derbeneva, O., Golhar, R., Golik, P., O'Hearn, S., Levy, S., Potluri, P., Lvova, M. ., Davila, A., Lin, CS, Perin, JC, Rappaport, EF, Hakonarson, H., Trounce, IA, Procaccio, V., & Wallace, DC (2014). Kev nce qib hauv mtDNA 3243A>G heteroplasmy ua rau kev hloov pauv sai sai. Cov txheej txheem ntawm National Academy of Sciences, 111(38), E4033–E4042. https://doi.org/10.1073/pnas.1414028111
Safiulina, D., & Kaasik, A. (2013). Lub zog thiab Dynamic: Yuav ua li cas Mitochondria ntsib Neuronal Energy Demands. PLOS, 11(12), e1001755. https://doi.org/10.1371/journal.pbio.1001755
Spinelli, JB, & Haigis, MC (2018). Lub Multifaceted Pab Pawg ntawm Mitochondria rau Cellular Metabolism. Xeev Cell Biology, 20(7), 745-754. https://doi.org/10.1038/s41556-018-0124-1
West, AP, Shadel, GS, & Ghosh, S. (2011). Mitochondria nyob rau hauv lub cev tiv thaiv kab mob. Nature Reviews Immunology, 11(6), Tshooj 6. https://doi.org/10.1038/nri2975
Zhu, X.H., Qiao, H., Du, F., Xiong, Q., Liu, X., Zhang, X., Ugurbil, K., & Chen, W. (2012). Quantitative imaging ntawm lub zog siv nyob rau hauv tib neeg lub hlwb. NeuroImage, 60(4), 2107-2117. https://doi.org/10.1016/j.neuroimage.2012.02.013
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